[血清素转运体基因SLC6A4多态性与抑郁症的关联]

[The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression].

作者信息

Gafarov V V, Gromova E A, Gubina M A, Gagulin I V, Maksimov V N, Gafarova A V

机构信息

Research Institute of Therapy and Preventive Medicine - branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(2):135-139. doi: 10.17116/jnevro2024124021135.

DOI:10.17116/jnevro2024124021135

PMID:38465822

Abstract

OBJECTIVE

To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25-44 years in Novosibirsk.

MATERIAL AND METHODS

Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample of people aged 25-44 years from the population of the Oktyabrsky district of Novosibirsk (men =725, mean age 43.4±0.4 years, response - 71.3%, women =710, mean age 44.8±0.4 years, response - 72%). Depression was assessed using the MONICA-MOPSY psychosocial questionnaire. Every fourth respondent was examined for polymorphic variants of 5HTTLPR-VNTR SNP rs25531 A>G of the SLC6A4 gene. The study was carried out within the framework of the budget topic Reg. No. 122031700094-5.

RESULTS

The high level of depression among people aged 25-44 was 12.8% (for men 9.1%, for women - 15.92%); the average level of depression occurred in 24.5% of the population (among men in 21.24%, among women in 26.76%) (χ=17.071, df=2, <0.001). The most common genotype of the SLC6A4 gene, among people aged 25--4 years old in Novosibirsk, was SLA - 43.29%, LALA - 26.53% - in second place, SS - 17.87% - third, LALG - 6 genotypes were less represented genotypes. 74%, SLG - 4.18%, LGLG - 1.39%. Carrying the SLA genotype (53.3% and 63.6%) increased the chance of developing both the average level of depression by 2.359 (95% CI 1.278-4.355) times, and depression in general by 1.933 (95% CI 1.142-3.271) times, compared with persons carrying the LALA genotype (32.0% and 46.9%), (χ=7.674, df=1, <0.01 and χ=6.095, df=1, <0.05). Persons carrying the LALG genotype (54.5%) also had a higher chance of developing a mean level of depression RR=2.929 (95% CI 1.039-8.261), compared with carriers of the LALA genotype (32.0%) (χ=4.326, df =1, <0.05) (<0.05).

CONCLUSION

Associative links between polymorphic variants of the SLC6A4 gene and depression have been established.

摘要

目的

研究新西伯利亚25 - 44岁人群中SLC6A4基因多态性变异与抑郁症之间的关系。

材料与方法

在世卫组织“莫妮卡 - 心理社会（MOPSY）”项目下，从新西伯利亚十月区人口中随机抽取了25 - 44岁的代表性样本（男性 = 725人，平均年龄43.4±0.4岁，应答率 - 71.3%；女性 = 710人，平均年龄44.8±0.4岁，应答率 - 72%）。使用莫妮卡 - MOPSY心理社会问卷评估抑郁症。每四位受访者中就有一位接受SLC6A4基因5HTTLPR - VNTR SNP rs25531 A>G多态性变异检测。该研究是在预算课题编号为122031700094 - 5的框架内进行的。

结果

25 - 44岁人群中抑郁症的高水平为12.8%（男性为9.1%，女性为15.92%）；抑郁症的平均水平出现在24.5%的人群中（男性为21.24%，女性为26.76%）（χ = 17.071，自由度 = 2，<0.001）。在新西伯利亚25 - 44岁人群中，SLC6A4基因最常见的基因型是SLA - 43.29%，LALA - 26.53%位居第二，SS - 17.87%位居第三，LALG - 6种基因型是较少见的基因型，占74%，SLG - 4.18%，LGLG - 1.39%。与携带LALA基因型（32.0%和46.9%）的人相比，携带SLA基因型（53.3%和63.6%）的人出现抑郁症平均水平的几率增加了2.359倍（95%置信区间1.278 - 4.355），患总体抑郁症的几率增加了1.933倍（95%置信区间1.142 - 3.271）（χ = 7.674，自由度 = 1，<0.01；χ = 6.095，自由度 = 1，<0.05）。与携带LALA基因型（32.0%）的人相比，携带LALG基因型（54.5%）的人出现抑郁症平均水平的风险也更高，相对风险RR = 2.929（95%置信区间1.039 - 8.261）（χ = 4.326，自由度 = 1，<0.05）（<0.05）。