Gafarov Valery, Gromova Elena, Shakhtshneider Elena, Gagulin Igor, Gafarova Almira
Institute of Internal and Preventive Medicine (IIPM)-Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, Russia.
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases (CVD), 175/1 Borisa Bogatkova Str., Novosibirsk 630089, Russia.
J Pers Med. 2023 Aug 26;13(9):1306. doi: 10.3390/jpm13091306.
The gene polymorphism is associated with the risk of the development of several neurological disorders. The aim of the study was to investigate the association of the gene polymorphism with depression in the white adult population aged 25-64 years in Novosibirsk (Western Siberia). The third screening of the WHO program "MONICA-psychosocial" was conducted in 1994-1995. In total, 403 men (the average age was 34 ± 0.4 years, the response was 71%) and 531 women (the average age was 35 ± 0.4 years, the response was 72%) of the open population of residents aged 25-64 years of the Oktyabrsky district of Novosibirsk were examined. The "MONICA-MOPSY" psychosocial questionnaire was used to assess depression. A high level of depression was found in 12.8% of the population: in 8.9% of men and in 15.8% of women. The frequencies of gene polymorphism genotypes ε2/3, ε2/4, ε3/3, ε3/4, and ε4/4 were 14.9%, 3.1%, 61.6%, 17.5%, and 2.9%, respectively. Carrying the ε3/4 genotype of the gene increased the odds of developing major depression by 2.167 times (95% CI 1.100-4.266) compared to carrying the ε3/3 genotype of the gene in people without depression (χ = 5.120 df = 1 = 0.024). Carriers of the ε4 allele were 2.089 times (95% CI 1.160-3.761) more likely to have a high level of depression than those without this allele and no depression (χ = 6.148 df = 1 = 0.013), and 2.049 times (95% CI 1.117-3.758) more likely to have a moderate level of depression than those without this allele (χ = 5.470 df = 1 < 0.019). The ε4 allele of the gene is associated with a high level of depression.
基因多态性与多种神经系统疾病的发生风险相关。本研究旨在调查新西伯利亚（西西伯利亚）25 - 64岁白人成年人群中该基因多态性与抑郁症的关联。1994 - 1995年开展了世界卫生组织“MONICA - 心理社会”项目的第三次筛查。总共对新西伯利亚奥克佳布里斯基区25 - 64岁常住开放人群中的403名男性（平均年龄34 ± 0.4岁，应答率71%）和531名女性（平均年龄35 ± 0.4岁，应答率72%）进行了检查。使用“MONICA - MOPSY”心理社会问卷评估抑郁症。在12.8%的人群中发现了高水平的抑郁症：男性中为8.9%，女性中为15.8%。该基因多态性基因型ε2/3、ε2/4、ε3/3、ε3/4和ε4/4的频率分别为14.9%、3.1%、61.6%、17.5%和2.9%。与无抑郁症人群中携带该基因ε3/3基因型相比，携带该基因ε3/4基因型会使患重度抑郁症的几率增加2.167倍（95%置信区间1.100 - 4.266）（χ = 5.120，自由度 = 1，P = 0.024）。携带ε4等位基因的人群患高水平抑郁症的可能性比不携带该等位基因且无抑郁症的人群高2.089倍（95%置信区间1.160 - 3.761）（χ = 6.
