铑（I）催化单氟二烯与硼酸的脱氟双芳基化反应
Rhodium(I)-Catalyzed Defluorinative Bisarylation of Monofluorodienes with Boronic Acids.
作者信息
Li Min, Tsui Gavin Chit
机构信息
Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR 999077, China.
出版信息
Org Lett. 2024 Mar 22;26(11):2223-2227. doi: 10.1021/acs.orglett.4c00383. Epub 2024 Mar 11.
Abstract
We herein describe a Rh(I)-catalyzed bisarylation reaction of monofluorodienes using arylboronic acids. Two aryl groups are installed in the trisubstituted ()-alkene products in one step with excellent diastereoselectivities. An intriguing reaction sequence of Rh(I)-catalyzed 1,6-addition followed by defluorinative coupling is proposed for product formation.
摘要
我们在此描述了一种使用芳基硼酸对单氟二烯进行铑（I）催化的双芳基化反应。两个芳基在一步反应中被引入到三取代（）-烯烃产物中，具有出色的非对映选择性。对于产物的形成，我们提出了一个有趣的反应序列，即铑（I）催化的1,6-加成，随后是脱氟偶联反应。
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