离子液体介导的传递体用于胰岛素经皮给药。
Ionic liquid-mediated ethosome for transdermal delivery of insulin.
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore-7408, Bangladesh.
出版信息
Chem Commun (Camb). 2024 Apr 9;60(30):4036-4039. doi: 10.1039/d3cc06130b.
Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl--3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.
在此，我们报告了一种基于 1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱（DMPC）的离子液体的醇质体（ET）制剂，其中含有安全浓度的乙醇作为载体，用于透皮递送达分子量药物胰岛素。与常规的 DMPC ET 相比，负载胰岛素的 ET 囊泡表现出长期稳定性，显示出更高的药物包封效率和增加的皮肤渗透能力。
Zotero 插件