Jain Ankit, Shakya Ashok K, Prajapati Shiv Kumar, Eldesoqui Mamdouh, Mody Nishi, Jain Sanjay K, Naik Rajashri R, Patil Umesh K
Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Pilani Campus, Pilani, India.
Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
Front Bioeng Biotechnol. 2024 Aug 6;12:1454247. doi: 10.3389/fbioe.2024.1454247. eCollection 2024.
Ionic liquids (ILs) represent an exciting and promising solution for advancing drug delivery platforms. Their unique properties, including broad chemical diversity, adaptable structures, and exceptional thermal stability, make them ideal candidates for overcoming challenges in transdermal drug delivery. Despite encountering obstacles such as side reactions, impurity effects, biocompatibility concerns, and stability issues, ILs offer substantial potential in enhancing drug solubility, navigating physiological barriers, and improving particle stability. To propel the use of IL-based drug delivery in pharmaceutical innovation, it is imperative to devise new strategies and solvents that can amplify drug effectiveness, facilitate drug delivery to cells at the molecular level, and ensure compatibility with the human body. This review introduces innovative methods to effectively address the challenges associated with transdermal drug delivery, presenting progressive approaches to significantly improve the efficacy of this drug delivery system.
离子液体（ILs）是推进药物递送平台的一种令人兴奋且前景广阔的解决方案。它们具有独特的性质，包括广泛的化学多样性、可适应的结构和出色的热稳定性，使其成为克服经皮药物递送挑战的理想候选者。尽管遇到诸如副反应、杂质效应、生物相容性问题和稳定性问题等障碍，但离子液体在提高药物溶解度、跨越生理屏障和改善颗粒稳定性方面具有巨大潜力。为了推动基于离子液体的药物递送在药物创新中的应用，必须设计新的策略和溶剂，以增强药物疗效、在分子水平上促进药物向细胞的递送并确保与人体的相容性。本综述介绍了有效应对经皮药物递送相关挑战的创新方法，展示了显著提高该药物递送系统疗效的渐进方法。
