Biological Engineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Beni Mellal, Morocco.
High Institute of Nursing Professions and Health Techniques Dakhla Annex, Dakhla, Morocco.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep;397(9):6591-6609. doi: 10.1007/s00210-024-03035-5. Epub 2024 Mar 11.
Glyphosate-based Herbicide (GBH) is a widely used pesticide that functions as a broad-spectrum, non-selective herbicide. Despite advanced research to describe the neurotoxic potential of GBH, the harmful effects on maternal behavior and neurodevelopment of offspring remain unclear. This study was conducted to highlight the effects of GBH on the antioxidant system, anxiety traits, social interaction, and cognitive and sensorimotor functions in pups exposed to 25 or 50 mg/l daily via their mother's milk. Concerning the biochemical biomarkers, GBH administered during the early stages of development negatively affected the status of antioxidant enzymes and lipid peroxidation in the brain structures of the pups. Furthermore, our results showed a significant decrease in acetylcholinesterase (AChE) specific activity within the brains of treated pups. The results of the behavioral tests indicated that the treated offspring developed anxiety, memory, and sociability disorders, as evidenced by the Open Field, Y-maze, object recognition task, and social interaction tests. Through neurodevelopmental testing, we also showed sensorimotor impairment (righting reflex and negative geotaxis) and abnormal maternal behavior. Altogether, our study clearly demonstrates that the developing brain is sensitive to GBH.
草甘膦基除草剂（GBH）是一种广泛使用的农药，具有广谱、非选择性的除草作用。尽管已经进行了先进的研究来描述 GBH 的神经毒性潜力，但它对母体行为和后代神经发育的有害影响仍不清楚。本研究旨在强调草甘膦基除草剂通过母奶每天以 25 或 50mg/L 的剂量暴露于后代时，对其抗氧化系统、焦虑特征、社交互动以及认知和感觉运动功能的影响。关于生化生物标志物，在发育早期给予草甘膦基除草剂会对幼仔大脑结构中的抗氧化酶和脂质过氧化状态产生负面影响。此外，我们的研究结果显示，处理过的幼仔大脑中的乙酰胆碱酯酶（AChE）特异性活性显著降低。行为测试的结果表明，受处理的后代出现了焦虑、记忆和社交障碍，这可以通过旷场、Y 迷宫、物体识别任务和社交互动测试得到证明。通过神经发育测试，我们还发现了感觉运动障碍（翻正反射和负趋地性）和异常的母体行为。总之，我们的研究清楚地表明，发育中的大脑对草甘膦基除草剂很敏感。
