School of Pharmacy, LNCT University, Bhopal, M.P., India.
Department of Pharmaceutical Sciences, , Bhagyoday Tirth Pharmacy College Sagar, M.P., India.
J Biomater Sci Polym Ed. 2022 Dec;33(18):2406-2432. doi: 10.1080/09205063.2022.2103625. Epub 2022 Jul 27.
Various types of skin disorders across each age group and in each part of geographical world are very dreadful. Despite not being fatal each time they are always of social and mental concern for suffering individuals, causing complications in millions of patients every day and require comparatively longer duration of treatment. Off late, various topical/transdermal formulations have been widely explored for the treatment of various skin ailments. The efficiency of topical therapy depends on various physiochemical properties of drugs like particle size, particle size distribution, partition coefficient, viscosity of dosage form, skin permeability, skin condition and the site of application. Therefore, in plenty of examples, long-acting topical formulations have shown to be markedly excellent in comparison to conventional dosage forms. The major advantages of topical formulations accrue from their demonstrated ability: (i) Reduced serious side effects that may occur due to undesirably higher systemic absorption of drug. (ii) Enhancement of drug accumulation at the desired site. (iii) Easy incorporation of enormous range of hydrophilic and hydrophobic drugs and (iv) Reduced risk of dose dumping and comparatively easy termination of drug release. The prospective applications of topically applied formulations and the deposition of pharmaceuticals into the skin are examined.
各种类型的皮肤疾病在每个年龄组和地理区域都很可怕。尽管它们并不总是致命的，但每次都会引起受影响个体的社会和心理关注，每天都会给数百万患者带来并发症，并且需要相对较长的治疗时间。最近，人们广泛探索了各种局部/透皮制剂来治疗各种皮肤疾病。局部治疗的效果取决于药物的各种物理化学性质，如粒径、粒径分布、分配系数、剂型的粘度、皮肤渗透性、皮肤状况和应用部位。因此，在许多情况下，长效局部制剂的表现明显优于传统剂型。局部制剂的主要优点来自于其明显的能力：（i）降低由于药物不期望的全身吸收过高而可能发生的严重副作用。（ii）增强药物在所需部位的积累。（iii）易于纳入大量的亲水和疏水药物，以及（iv）降低剂量倾倒的风险和相对容易终止药物释放。本文考察了局部应用制剂的应用前景和药物在皮肤中的沉积。
