糖尿病患者的睡眠时间与脂质代谢：来自POWER2DM研究
Sleep duration and lipid metabolism in patients with diabetes mellitus: from the POWER2DM study.
作者信息
Perez-Corral Isabel, Gomez-Delgado Francisco, Ruissen Merel M, Torres-Peña Jose D, Larriva Antonio P Arenas-de, Sont Jacob K, de Graaf Albert A, Uitbeijerse Bas S, de Koning Eelco J P, Delgado-Lista Javier
机构信息
Lipids and Atherosclerosis Unit, Internal Medicine Unit, Reina Sofia University Hospital, Avda. Menendez Pidal, S/N., 14004 Cordoba, Spain.
Department of Medical and Surgical Sciences, University of Cordoba, 14004 Cordoba, Spain.
出版信息
Sleep Biol Rhythms. 2022 Aug 5;20(4):595-599. doi: 10.1007/s41105-022-00403-7. eCollection 2022 Oct.
This study assesses the association between sleep duration and plasma lipid profiles in people with diabetes mellitus (DM). Sleep duration data were obtained in 91 patients from the POWER2DM study (NCT03588104). The patients were divided in tertiles, based on their sleep duration, and blood samples were obtained at the beginning and after 9 months. Significant differences were found, specifically, patients in Tertile 3 (≥ 7.51 h) showed lower plasma levels of high-density lipoprotein cholesterol HDL-c ( < 0.05), apolipoprotein A1 (apo-A1; < 0.05) and low HDL-c/apo-A1 ratio ( < 0.05). This study shows that sleep duration is associated with plasma lipid profiles in people with DM.
本研究评估了糖尿病（DM）患者的睡眠时间与血浆脂质谱之间的关联。睡眠时间数据来自POWER2DM研究（NCT03588104）中的91名患者。根据睡眠时间将患者分为三分位数，并在开始时和9个月后采集血样。发现了显著差异，具体而言，第三三分位数（≥7.51小时）的患者血浆高密度脂蛋白胆固醇HDL-c水平较低（<0.05），载脂蛋白A1（apo-A1；<0.05）以及低HDL-c/apo-A1比值（<0.05）。本研究表明，睡眠时间与糖尿病患者的血浆脂质谱相关。
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