Department of Endocrinology and Diabetes, Royal College of Surgeons in Ireland, Connolly Hospital, Blanchardstown, Dublin 15, Ireland.
Int J Endocrinol. 2013;2013:341506. doi: 10.1155/2013/341506. Epub 2013 Aug 29.
Aim. To investigate the association between sleep quality and duration with lipid and glycaemic control in Caucasian subjects with type 2 diabetes. Methods. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in 114 type 2 diabetes (T2DM) subjects. Comparisons were made between subjects with different sleep quality and sleep duration. Hierarchical multiple regression analyses were used to determine contributors to metabolic parameters. Results. Subjects with poor sleep quality (PQ; PSQI ≥ 6) had higher systolic blood pressure, glycated haemoglobin, urine albumin : creatinine ratio (UAC), total cholesterol (TC), and triglycerides (TG) (P < 0.05 for all) compared to those with good sleep quality (GQ; PSQI ≤ 5). Long sleep duration (LSD) subjects had higher TC and short sleep duration (SSD) subjects had higher TG compared to those with medium sleep duration. Sleep duration and PSQI score were independent predictors of TC and low-density lipoprotein cholesterol (LDL), contributing to 14.0% and 6.1% of the total variance, respectively. Conclusions. In this Caucasian T2DM population, PQ is associated with adverse cardiovascular risk markers, and long and short sleep disruptions have an independent negative impact on lipids. Sleep assessment should be included as part of a diabetes clinic review.
目的。调查白种人 2 型糖尿病患者的睡眠质量和时长与血脂和血糖控制之间的关系。方法。使用匹兹堡睡眠质量指数（PSQI）对 114 例 2 型糖尿病（T2DM）患者的睡眠质量进行评估。比较了不同睡眠质量和睡眠时长的患者。采用分层多元回归分析确定代谢参数的影响因素。结果。睡眠质量差（PSQI≥6）的患者收缩压、糖化血红蛋白、尿白蛋白与肌酐比值（UAC）、总胆固醇（TC）和甘油三酯（TG）均高于睡眠质量好（PSQI≤5）的患者（均 P<0.05）。长睡眠时长（LSD）患者 TC 较高，短睡眠时长（SSD）患者 TG 较高，而中睡眠时长患者 TC 和 LDL 较高。睡眠时长和 PSQI 评分是 TC 和 LDL 的独立预测因子，分别占总方差的 14.0%和 6.1%。结论。在这个白种人 2 型糖尿病人群中，睡眠质量差与不良心血管风险标志物相关，长时和短时睡眠紊乱对血脂有独立的负面影响。睡眠评估应作为糖尿病临床评估的一部分。
