辅酶Q10对阿霉素诱导的心脏毒性的保护作用：范围综述文章。
Protective effect of coenzyme Q10 against doxorubicin-induced cardiotoxicity: Scoping review article.
作者信息
Qahtani Abdullah Al, Balawi Hamed Al, Jowesim Fahad Al
机构信息
King Faisal University, Collage of Clinical Pharmacy, Alahsa, Saudi Arabia.
Ministry of National Guards Health Affairs, King Abdulaziz Hospital, Alahsa, Saudi Arabia.
出版信息
Saudi Pharm J. 2024 Feb;32(2):101882. doi: 10.1016/j.jsps.2023.101882. Epub 2023 Nov 21.
INTRODUCTION
Doxorubicin (dox) is classified as an antineoplastic antibiotic which is known as adriamycin from the anthracycline group. Due to the release of free radicals and lipid peroxidation which can cause acute cardiotoxicity. Coenzyme Q10 is found in many cells of the body, it is an antioxidant that reduces oxidative stress and lipid peroxidation.
AIM
This scoping review aims to evaluate the cardioprotective effect of coenzyme Q10 in doxorubicin-induced cardiotoxicity in animals.
METHODS
This review was done based on Arksey and O'Malley's methodology, reviewing published articles from October 1978 and September 2023.
RESULTS
14 out of 11,303 articles were included from the initial search, (10 out of 14 articles found that coenzyme Q10 protect has a protection effect against doxorubicin-induced cardiotoxicity).
CONCLUSION
The results of this review found coenzyme Q10 protects against doxorubicin cardiotoxicity. It is a promising supplement that could be used to prevent cardiotoxicity induced by doxorubicin in cancer patients.
引言
阿霉素（多柔比星）被归类为一种抗肿瘤抗生素，属于蒽环类抗生素中的阿霉素。由于自由基的释放和脂质过氧化会导致急性心脏毒性。辅酶Q10存在于人体的许多细胞中，它是一种抗氧化剂，可减少氧化应激和脂质过氧化。
目的
本综述旨在评估辅酶Q10对阿霉素诱导的动物心脏毒性的心脏保护作用。
方法
本综述基于阿克西和奥马利的方法进行，回顾了1978年10月至2023年9月发表的文章。
结果
初步检索得到的11303篇文章中有14篇被纳入，（14篇文章中有10篇发现辅酶Q10对阿霉素诱导的心脏毒性有保护作用）。
结论
本综述结果发现辅酶Q10可预防阿霉素的心脏毒性。它是一种有前景的补充剂，可用于预防癌症患者中由阿霉素诱导的心脏毒性。
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