Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Cell Death Dis. 2021 Apr 1;12(4):339. doi: 10.1038/s41419-021-03614-x.
Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.
多柔比星是一种用于治疗各种恶性肿瘤的化疗药物；然而，患者可能会出现心脏毒性作用，这限制了这种强效药物的使用。多柔比星杀死心肌细胞的机制一直难以捉摸，尽管进行了广泛的研究，但确切的机制仍不清楚。本综述重点介绍了我们对多柔比星诱导的调节性心肌细胞死亡途径的最新认识，包括自噬、铁死亡、坏死性凋亡、细胞焦亡和细胞凋亡。了解多柔比星导致心肌细胞死亡的机制可能有助于确定新的治疗剂，并导致更有针对性的心脏毒性测试方法。
