Li Fan, Zhao Qi, Tang Tongyu, Liu Yuyuan, Wang Zhaodi, Wang Zhi, Han Xiaoping, Xu Zifeng, Chang Yu, Li Yuqin
Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China.
Norman Bethune Health Science Center, Jilin University, Changchun, China.
Front Immunol. 2024 Feb 26;15:1359540. doi: 10.3389/fimmu.2024.1359540. eCollection 2024.
Inflammatory bowel disease (IBD), mainly categorized into Crohn's disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients' quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of investigation.
We conducted a Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from the UK Biobank database to investigate the causal relationships between IBD and alterations in brain structural morphology and connectivity of neural tracts. This study aimed to identify biological evidence linking IBD to psychiatric disorders such as anxiety and depression.
Specifically, the volume of grey matter in the Left Frontal Orbital Cortex exhibited a negative association with the onset of Crohn's disease (odds ratio (OR) [95% confidence interval (CI)]: 0.315[0.1800.551], adjusted P=0.001), while the volume of the superior frontal cortex in the right hemisphere showed a positive correlation with the development of Ulcerative colitis (OR [95% CI]: 2.285[1.7932.911], adjusted P<0.001), and the volume of lateral occipital cortex in the left hemisphere demonstrated a positive relationship with Crohn's disease onset (OR [95% CI]: 1.709[1.671~1.747], adjusted P<0.001). In the context of reverse causality, the onset of UC or CD has led to alterations in imaging derived phenotypes associated with five disorders (anxiety, depression, schizophrenia, bipolar disorder, pain) and three functions (memory, emotion, language).
Our study has demonstrated a causal relationship between IBD and IDPs. IDPs may serve as potential biomarkers for the progression of IBD and as predictive intermediaries for the development of neurological diseases in IBD patients.
炎症性肠病（IBD）主要分为克罗恩病（CD）和溃疡性结肠炎（UC），是一种慢性复发性胃肠道疾病，严重损害患者的生活质量。IBD患者常伴有焦虑和抑郁等合并症，其潜在机制和治疗策略仍是研究领域。
我们利用英国生物银行数据库中源自脑图像的表型（IDP）进行了孟德尔随机化（MR）分析，以研究IBD与脑结构形态改变及神经通路连接性之间的因果关系。本研究旨在确定将IBD与焦虑和抑郁等精神障碍联系起来的生物学证据。
具体而言，左侧额眶皮质的灰质体积与克罗恩病的发病呈负相关（优势比（OR）[95%置信区间（CI）]：0.315[0.1800.551]，校正P=0.001），而右侧半球额上皮质的体积与溃疡性结肠炎的发展呈正相关（OR[95%CI]：2.285[1.7932.911]，校正P<0.001），左侧半球枕外侧皮质的体积与克罗恩病的发病呈正相关（OR[95%CI]：1.709[1.671~1.747]，校正P<0.001）。在反向因果关系方面，UC或CD的发病导致了与五种疾病（焦虑、抑郁、精神分裂症、双相情感障碍、疼痛）和三种功能（记忆、情感、语言）相关的影像衍生表型的改变。
我们的研究证明了IBD与IDP之间存在因果关系。IDP可能作为IBD进展的潜在生物标志物，并作为IBD患者神经疾病发展的预测中介。
