用于对映选择性铑（I）催化的凹形P-立体异构磷酰胺酯配体
Concave P-Stereogenic Phosphorodiamidite Ligands for Enantioselective Rh(I) Catalysis.
作者信息
Saleh Nidal, Besnard Céline, Lacour Jérôme
机构信息
Department of Organic Chemistry, University of Geneva, 1211 Geneva 4, Switzerland.
Laboratory of Crystallography, University of Geneva, 1211 Geneva 4, Switzerland.
出版信息
Org Lett. 2024 Mar 22;26(11):2202-2206. doi: 10.1021/acs.orglett.4c00371. Epub 2024 Mar 12.
The development of a new class of concave P-stereogenic phosphorodiamidite ligands, derived from Tröger's bases (TBs), is explored. These ligands, characterized by their remarkable stability and unique structural geometry around the P atom, are used in asymmetric Rh(I)-catalyzed additions of boronic acids to NH-isatins resulting in excellent reactivities and reasonable enantioselectivity (er up to 92:8).
本文探索了一类新型的源自特罗格碱（TBs）的凹形P-手性磷酰胺配体的开发。这些配体具有显著的稳定性以及P原子周围独特的结构几何特征，用于铑（I）催化的硼酸对NH-异吲哚酮的不对称加成反应，反应具有出色的反应活性和合理的对映选择性（对映体比例高达92:8）。
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