易于获得的手性二烯配体用于 Rh 催化的硼酸对映选择性共轭加成反应。

Readily accessible chiral diene ligands for Rh-catalyzed enantioselective conjugate additions of boronic acids.

机构信息

Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.

出版信息

Org Lett. 2011 Sep 2;13(17):4566-9. doi: 10.1021/ol201754c. Epub 2011 Aug 11.

DOI:10.1021/ol201754c

Abstract

Enabled by the broad scope of the Pd-catalyzed asymmetric alkylation of meso- and d,l-divinylethylene carbonate, several chiral diene ligands were prepared in two steps from commercial materials. Subsequently, these ligands were evaluated in the Rh-catalyzed asymmetric conjugate addition of boronic acids to enones.

摘要

在 Pd 催化的 meso-和 d,l-二乙烯基碳酸酯不对称烷基化的广泛应用下，几种手性二烯配体可以从商业原料出发，经两步反应制备得到。随后，这些配体在 Rh 催化的硼酸对烯酮的不对称共轭加成反应中得到了评估。