Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.
Polatlı Duatepe State Hospital, Ankara, Türkiye.
Eye (Lond). 2024 Jun;38(9):1714-1721. doi: 10.1038/s41433-024-03007-2. Epub 2024 Mar 12.
To compare qualitative and quantitative features of type 1 macular neovascularizations (MNV) in pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD).
Forty-three treatment-naive eyes of 41 PNV patients and 40 treatment-naive eyes of 38 patients with nAMD were included. The patients were classified as PNV or nAMD according to the presence of pachychoroid features and soft/reticular drusen. Presence of central trunk and maturity of the MNV were evaluated on optical coherence tomography angiography (OCTA) images. MNV area, vessel density (VD), total vessel length (VL), number of intersection points (IPs), fractal dimension (FD), and lacunarity (LAC) were calculated using ImageJ software and FracLac plugin.
The mean age was 56.8 ± 8.7 years in PNV and 70.4 ± 8.8 years in neovascular AMD groups (p < 0.001). Compared to nAMD, the presence of central trunk was less frequent in PNV (48.8% vs 77.5%, p = 0.007). Immature MNV pattern was observed more frequently in PNV eyes than nAMD (41.9% vs 20.0%, p = 0.009). PNV cases had significantly lower median MNV area [0.913(1.115) vs 2.542(3.273) mm²], total VL [14.84 (20.46) vs 36.34 (44.68) mm], number of IPs [104(140) vs 335(417.3)], and FD [1.56(0.10) vs 1.59(0.11)] comparing to nAMD cases (p < 0.001, p = 0.001, p < 0.001, p = 0.043 respectively). However, the mean VD (42.4 ± 6.8 vs 42.9 ± 9.0%) and the median LAC values [0.42 (0.09) vs 0.42 (0.09)] did not differ significantly between groups (p = 0.776, p = 0.526, respectively).
Morphological and quantitative differences exist in type 1 neovascular lesions. Type 1 MNVs in the PNV group are characterized by a smaller and less complex structure.
比较厚脉络膜新生血管（pachychoroid neovascularization，PNV）和新生血管性年龄相关性黄斑变性（neovascular age-related macular degeneration，nAMD）中 1 型黄斑新生血管（macular neovascularization，MNV）的定性和定量特征。
纳入 41 例 PNV 患者的 43 只未经治疗的眼和 38 例 nAMD 患者的 40 只未经治疗的眼。根据存在厚脉络膜特征和软/网状玻璃膜疣将患者分类为 PNV 或 nAMD。使用光学相干断层扫描血管造影（optical coherence tomography angiography，OCTA）图像评估中央干和 MNV 的成熟度。使用 ImageJ 软件和 FracLac 插件计算 MNV 面积、血管密度（vessel density，VD）、总血管长度（total vessel length，VL）、交点数量（number of intersection points，IPs）、分形维数（fractal dimension，FD）和镶嵌度（lacunarity，LAC）。
PNV 组的平均年龄为 56.8±8.7 岁，nAMD 组为 70.4±8.8 岁（p<0.001）。与 nAMD 相比，PNV 中中央干的存在频率较低（48.8% vs 77.5%，p=0.007）。PNV 眼的不成熟 MNV 模式更为常见，高于 nAMD 眼（41.9% vs 20.0%，p=0.009）。与 nAMD 相比，PNV 病例的 MNV 面积[0.913（1.115）vs 2.542（3.273）mm²]、总 VL[14.84（20.46）vs 36.34（44.68）mm]、IP 数量[104（140）vs 335（417.3）]和 FD[1.56（0.10）vs 1.59（0.11）]均较低（p<0.001、p=0.001、p<0.001、p=0.043）。然而，两组的平均 VD（42.4±6.8 vs 42.9±9.0%）和中位数 LAC 值[0.42（0.09）vs 0.42（0.09）]差异无统计学意义（p=0.776、p=0.526）。
1 型新生血管病变存在形态和定量差异。PNV 组的 1 型 MNV 具有更小、更简单的结构特征。
