多参数磁共振成像与微超声对既往活检阴性患者临床显著性前列腺癌检测的比较评估
A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies.
作者信息
Beatrici Edoardo, Frego Nicola, Chiarelli Giuseppe, Sordelli Federica, Mancon Stefano, Saitta Cesare, De Carne Fabio, Garofano Giuseppe, Arena Paola, Avolio Pier Paolo, Gobbo Andrea, Uleri Alessandro, Contieri Roberto, Paciotti Marco, Lazzeri Massimo, Hurle Rodolfo, Casale Paolo, Buffi Nicolò Maria, Lughezzani Giovanni
机构信息
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy.
Department of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.
出版信息
Diagnostics (Basel). 2024 Mar 1;14(5):525. doi: 10.3390/diagnostics14050525.
BACKGROUND
The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases.
METHODS
A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa).
RESULTS
In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15-37.8; = 0.035).
CONCLUSIONS
mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted.
背景
活检结果为阴性后的前列腺癌诊断过程具有挑战性。本研究比较了微超声（mUS）与多参数磁共振成像（mpMRI）对此类病例的诊断准确性。
方法
进行了一项回顾性队列研究，目标是既往活检结果为阴性的男性，使用mUS和mpMRI检测前列腺癌及临床显著性前列腺癌（csPCa）。
结果
在我们1397名男性的队列中，304人有活检阴性史。mUS比mpMRI更敏感，对阴性结果具有更好的预测价值。重要的是，mUS与csPCa检测显著相关（校正比值比[aOR]：6.58；95%置信区间[CI]：1.15 - 37.8；P = 0.035）。
结论
对于既往活检阴性的患者，mUS可能更适合诊断前列腺癌。然而，本研究在单一机构的回顾性设计表明，有必要在多个中心进行进一步研究。
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