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机器人辅助完全ALPPS(rALPPS)——德国的首例经验

Robotic Complete ALPPS (rALPPS)-First German Experiences.

作者信息

Arend Jörg, Franz Mareike, Rose Alexander, March Christine, Rahimli Mirhasan, Perrakis Aristotelis, Lorenz Eric, Croner Roland

机构信息

Department of General-, Visceral-, Vascular- and Transplant Surgery, University Hospital Magdeburg, 39120 Magdeburg, Germany.

Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, 39120 Magdeburg, Germany.

出版信息

Cancers (Basel). 2024 Mar 6;16(5):1070. doi: 10.3390/cancers16051070.

Abstract

BACKGROUND

ALPPS leads to fast and effective liver hypertrophy. This enables the resection of extended tumors. Conventional ALPPS is associated with high morbidity and mortality. MILS reduces morbidity and the robot adds technical features that make complex procedures safe.

MATERIAL AND METHODS

The MD-MILS was screened for patients who underwent rALPPS. Demographic and perioperative data were evaluated retrospectively. Ninety days postoperative morbidity was scored according to the CD classification. The findings were compared with the literature.

RESULTS

Since November 2021, five patients have been identified. The mean age and BMI of the patients were 50.0 years and 22.7 kg/m. In four cases, patients suffered from colorectal liver metastases and, in one case, intrahepatic cholangiocarcinoma. Prior to the first operation, the mean liver volume of the residual left liver was 380.9 mL with a FLR-BWR of 0.677%. Prior to the second operation, the mean volume of the residual liver was 529.8 mL with a FLR-BWR of 0.947%. This was an increase of 41.9% of the residual liver volume. The first and second operations were carried out within 17.8 days. The mean time of the first and second operations was 341.2 min and 440.6 min. The mean hospital stay was 27.2 days. Histopathology showed the largest tumor size of 39 mm in diameter with a mean amount of 4.7 tumors. The mean tumor-free margin was 12.3 mm. One complication CD > 3a occurred. No patient died during the 90-day follow up.

CONCLUSION

In the first German series, we demonstrated that rALPPS can be carried out safely with reduced morbidity and mortality in selected patients.

摘要

背景

联合肝脏分隔和门静脉结扎的二步肝切除术(ALPPS)可导致快速有效的肝肥大。这使得能够切除更大范围的肿瘤。传统的ALPPS与高发病率和死亡率相关。微创ALPPS(MILS)可降低发病率,而机器人手术增加了使复杂手术更安全的技术特性。

材料与方法

筛选接受机器人辅助ALPPS(rALPPS)的患者纳入MD-MILS研究。对人口统计学和围手术期数据进行回顾性评估。根据Clavien-Dindo(CD)分类对术后90天的发病率进行评分。将研究结果与文献进行比较。

结果

自2021年11月以来,共确定了5例患者。患者的平均年龄和体重指数分别为50.0岁和22.7kg/m²。4例患者患有结直肠癌肝转移,1例患有肝内胆管癌。在第一次手术前,剩余左肝的平均肝体积为380.9mL,未来肝残余体积-体重比(FLR-BWR)为0.677%。在第二次手术前,残余肝的平均体积为529.8mL,FLR-BWR为0.947%。残余肝体积增加了41.9%。第一次和第二次手术在17.8天内完成。第一次和第二次手术的平均时间分别为341.2分钟和440.6分钟。平均住院时间为27.2天。组织病理学显示最大肿瘤直径为39mm,平均肿瘤数量为4.7个。平均切缘无瘤距离为12.3mm。发生了1例Clavien-Dindo分级>3a级的并发症。在90天的随访期间无患者死亡。

结论

在德国的首个系列研究中,我们证明了rALPPS在特定患者中可以安全实施,且发病率和死亡率降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12c7/10930461/7a159eac2c23/cancers-16-01070-g001.jpg

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