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基于根形种植体的多孔结构参数化设计及最佳孔隙率梯度分布

Parametric Design of Porous Structure and Optimal Porosity Gradient Distribution Based on Root-Shaped Implants.

作者信息

Liu Lijian, Ma Shaobo, Zhang Yongkang, Zhu Shouxiao, Wu Shuxuan, Liu Guang, Yang Guang

机构信息

School of Mechanical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.

出版信息

Materials (Basel). 2024 Feb 29;17(5):1137. doi: 10.3390/ma17051137.

Abstract

Porous structures can reduce the elastic modulus of implants, decrease stress shielding, and avoid bone loss in the alveolar bone and aseptic loosening of implants; however, there is a mismatch between yield strength and elastic modulus as well as biocompatibility problems. This study aimed to investigate the parametric design method of porous root-shaped implants to reduce the stress-shielding effect and improve the biocompatibility and long-term stability and effectiveness of the implants. Firstly, the porous structure part was parametrically designed, and the control of porosity gradient distribution was achieved by using the fitting relationship between porosity and bias and the position function of bias. In addition, the optimal distribution law of the porous structure was explored through mechanical and hydrodynamic analyses of the porous structure. Finally, the biomechanical properties were verified using simulated implant-bone tissue interface micromotion values. The results showed that the effects of marginal and central porosity on yield strength were linear, with the elastic modulus decreasing from 18.9 to 10.1 GPa in the range of 20-35% for marginal porosity, with a maximum decrease of 46.6%; the changes in the central porosity had a more consistent effect on the elastic modulus, ranging from 18.9 to 15.3 GPa in the range of 50-90%, with a maximum downward shift of 19%. The central porosity had a more significant effect on permeability, ranging from 1.9 × 10 m to 4.9 × 10 m with a maximum enhancement of 61.2%. The analysis showed that the edge structure had a more substantial impact on the mechanical properties. The central structure could increase the permeability more effectively. Hence, the porous structure with reasonable gradient distribution had a better match between mechanical properties and flow properties. The simulated implantation results showed that the porous implant with proper porosity gradient distribution had better biomechanical properties.

摘要

多孔结构可以降低植入物的弹性模量,减少应力遮挡,并避免牙槽骨骨质流失和植入物无菌性松动;然而,屈服强度与弹性模量之间存在不匹配以及生物相容性问题。本研究旨在探讨多孔根形植入物的参数化设计方法,以降低应力遮挡效应,提高植入物的生物相容性、长期稳定性和有效性。首先,对多孔结构部分进行参数化设计,并通过孔隙率与偏差之间的拟合关系以及偏差的位置函数实现对孔隙率梯度分布的控制。此外,通过对多孔结构的力学和流体动力学分析,探索了多孔结构的最佳分布规律。最后,利用模拟的植入物 - 骨组织界面微动值验证了生物力学性能。结果表明,边缘孔隙率和中心孔隙率对屈服强度的影响呈线性关系,边缘孔隙率在20 - 35%范围内时,弹性模量从18.9 GPa降至10.1 GPa,最大降幅为46.6%;中心孔隙率的变化对弹性模量的影响更为一致,在50 - 90%范围内,弹性模量从18.9 GPa降至15.3 GPa,最大降幅为19%。中心孔隙率对渗透率的影响更为显著,范围从1.9×10⁻⁶ m²至4.9×10⁻⁶ m²,最大增幅为61.2%。分析表明,边缘结构对力学性能的影响更大,中心结构能更有效地增加渗透率。因此,具有合理梯度分布的多孔结构在力学性能和流动性能之间具有更好的匹配性。模拟植入结果表明,具有适当孔隙率梯度分布的多孔植入物具有更好的生物力学性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ed/10934482/d9a233ce75cd/materials-17-01137-g001.jpg

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