Trezza Alfonso, Geminiani Michela, Cutrera Giuseppe, Dreassi Elena, Frusciante Luisa, Lamponi Stefania, Spiga Ottavia, Santucci Annalisa
Department of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.
SienabioACTIVE, University of Siena, Via A. Moro, 53100 Siena, Italy.
Int J Mol Sci. 2024 Feb 21;25(5):2517. doi: 10.3390/ijms25052517.
Currently, many environmental and energy-related problems are threatening the future of our planet. In October 2022, the Worldmeter recorded the world population as 7.9 billion people, estimating that there will be an increase of 2 billion by 2057. The rapid growth of the population and the continuous increase in needs are causing worrying conditions, such as pollution, climate change, global warming, waste disposal, and natural resource reduction. Looking for novel and innovative methods to overcome these global troubles is a must for our common welfare. The circular bioeconomy represents a promising strategy to alleviate the current conditions using biomass-like natural wastes to replace commercial products that have a negative effect on our ecological footprint. Applying the circular bioeconomy concept, we propose an integrated in silico and in vitro approach to identify antioxidant bioactive compounds extracted from chestnut burrs (an agroforest waste) and their potential biological targets. Our study provides a novel and robust strategy developed within the circular bioeconomy concept aimed at target and drug discovery for a wide range of diseases. Our study could open new frontiers in the circular bioeconomy related to target and drug discovery, offering new ideas for sustainable scientific research aimed at identifying novel therapeutical strategies.
当前，许多与环境和能源相关的问题正威胁着我们星球的未来。2022年10月，世界ometers网站记录的世界人口为79亿，预计到2057年将增加20亿。人口的快速增长和需求的持续增加正导致令人担忧的状况，如污染、气候变化、全球变暖、废物处理和自然资源减少。寻找新颖和创新的方法来克服这些全球性问题对于我们的共同福祉至关重要。循环生物经济是一种有前景的策略，利用类似生物质的天然废物来替代对我们的生态足迹有负面影响的商业产品，以缓解当前状况。应用循环生物经济概念，我们提出了一种综合的计算机模拟和体外方法，以鉴定从栗苞（一种农林废弃物）中提取的抗氧化生物活性化合物及其潜在的生物学靶点。我们的研究提供了一种在循环生物经济概念内开发的新颖且强大的策略，旨在针对广泛疾病进行靶点和药物发现。我们的研究可为与靶点和药物发现相关的循环生物经济开辟新的前沿领域，为旨在确定新型治疗策略的可持续科学研究提供新思路。
