Rajanala Kalpana, Upadhyay Arun
Ocugen Inc., 11 Great Valley Parkway, Malvern, PA 19355, USA.
Int J Mol Sci. 2024 Feb 29;25(5):2840. doi: 10.3390/ijms25052840.
Retinal homeostasis, a tightly regulated process maintaining the functional integrity of the retina, is vital for visual function. Emerging research has unveiled the critical role of epigenetic regulation in controlling gene expression patterns during retinal development, maintenance, and response to mutational loads and injuries. Epigenetic switches, including DNA methylation, histone modifications, and non-coding RNAs, play pivotal roles in orchestrating retinal gene expression and cellular responses through various intracellular, extracellular, and environmental modulators. This review compiles the current knowledge on epigenetic switches in retinal homeostasis, providing a deeper understanding of their impact on retinal structural integrity and function and using them as potential targets for therapeutic interventions.
视网膜内环境稳定是一个严格调控的过程，维持着视网膜的功能完整性，对视觉功能至关重要。新兴研究揭示了表观遗传调控在视网膜发育、维持以及对突变负荷和损伤的反应过程中控制基因表达模式的关键作用。表观遗传开关，包括DNA甲基化、组蛋白修饰和非编码RNA，通过各种细胞内、细胞外和环境调节因子，在协调视网膜基因表达和细胞反应中发挥着关键作用。本综述汇集了关于视网膜内环境稳定中表观遗传开关的现有知识，更深入地了解它们对视网膜结构完整性和功能的影响，并将其作为治疗干预的潜在靶点。
