Lin Nicole, Erdos Thomas, Louie Carson, Desai Raina, Lin Naomi, Ayzenberg Gregory, Venketaraman Vishwanath
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Creighton University School of Medicine, Creighton University, Omaha, NE 68178, USA.
Int J Mol Sci. 2024 Mar 3;25(5):2952. doi: 10.3390/ijms25052952.
Human immunodeficiency virus (HIV) is a major cause of death worldwide. Without appropriate antiretroviral therapy, the infection can develop into acquired immunodeficiency syndrome (AIDS). AIDS leads to the dysregulation of cell-mediated immunity resulting in increased susceptibility to opportunistic infections and excessive amounts of inflammatory cytokines. HIV-positive individuals also demonstrate diminished glutathione (GSH) levels which allows for increased viral replication and increased pro-inflammatory cytokine release, further contributing to the high rates of mortality seen in patients with HIV. Adequate GSH supplementation has reduced inflammation and slowed the decline of CD4+ T cell counts in HIV-positive individuals. We aim to review the current literature regarding the role of GSH in cell-mediated immune responses in individuals with HIV- and AIDS-defining illnesses.
人类免疫缺陷病毒（HIV）是全球主要的死亡原因。如果没有适当的抗逆转录病毒疗法，感染会发展成获得性免疫缺陷综合征（AIDS）。AIDS导致细胞介导的免疫失调，从而增加了对机会性感染的易感性以及炎症细胞因子的过量产生。HIV阳性个体的谷胱甘肽（GSH）水平也会降低，这会导致病毒复制增加以及促炎细胞因子释放增加，进一步导致HIV患者的高死亡率。充足的GSH补充剂可减轻炎症，并减缓HIV阳性个体中CD4 + T细胞计数的下降。我们旨在综述有关GSH在患有HIV和AIDS相关疾病的个体的细胞介导免疫反应中的作用的当前文献。
