一种来自传统库尔德植物L.的具有癌细胞活力抑制活性的新型葡萄糖基黄酮及其他生物活性成分

A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant L.

作者信息

Amin Hawraz Ibrahim M, Amin Kamaran Younis M, Armijos Chabaco, Hussain Faiq H S, Jawhar Zanko Hassan, Caprioglio Diego, Mella Mariella, Vidari Giovanni

机构信息

Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, Iraq.

Department of Medical Biochemical Analysis, Cihan University-Erbil, Erbil 44001, Iraq.

出版信息

Molecules. 2024 Feb 29;29(5):1079. doi: 10.3390/molecules29051079.

DOI:10.3390/molecules29051079

PMID:38474591

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10933755/

Abstract

A new glucosyl flavone, 5,7,2',5'-tetrahydroxyflavone 7--β-d-glucopyranoside, named loeflingiin, together with apigenin 6--glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild L. () collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy. The structures of isolated compounds were determined by spectroscopic analysis. The activities of isovitexin and loeflingiinon the viability of breast (MCF7), ovarian (BG-1), endometrial (Ishikawa), and mesothelioma (IST-MES1) human cancer cells and two normal cell lines were determined with an MTT assay. Notably, the new 7--glucosyl flavone showed effects higher than cisplatin against the Ishikawa and IST-MESI cell lines. The significant biological activities exhibited by all the compounds isolated from provided scientific evidence to support the use of the plant in the Kurdish traditional medicine.

摘要

一种新的葡糖基黄酮，5,7,2',5'-四羟基黄酮7--β-d-吡喃葡萄糖苷，命名为洛弗林因，与芹菜素6--葡萄糖苷（异荭草素）、香豆素类的枸橼苦素和异茴芹内酯、三萜类的桦木醇和桦木酸，以及植物甾醇混合物β-谷甾醇、豆甾醇和菜油甾醇一起，首次从伊拉克库尔德地区采集的野生叶中分离得到。当地居民用这种植物治疗伤口并作为创伤治疗药物。通过光谱分析确定了分离化合物的结构。采用MTT法测定了异荭草素和洛弗林因对人乳腺癌（MCF7）、卵巢癌（BG-1）、子宫内膜癌（Ishikawa）和间皮瘤（IST-MES1）细胞系以及两种正常细胞系活力的影响。值得注意的是，这种新的7--葡糖基黄酮对Ishikawa和IST-MESI细胞系显示出比顺铂更高的作用效果。从该植物中分离得到的所有化合物所表现出的显著生物活性为库尔德传统医学中使用这种植物提供了科学依据。