镍（II）和镉（II）吡唑酰胺配位配合物的合成、晶体结构、遗传毒性以及抗真菌和抗菌研究
Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.
作者信息
El Mahdaoui Amal, Radi Smaail, Draoui Youssef, El Massaoudi Mohamed, Ouahhoud Sabir, Asehraou Abdeslam, Bentouhami Nour Eddine, Saalaoui Ennouamane, Benabbes Redouane, Robeyns Koen, Garcia Yann
机构信息
LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco.
Laboratory of Bioresource Biotechnology Ethnopharmacology and Health, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco.
出版信息
Molecules. 2024 Mar 6;29(5):1186. doi: 10.3390/molecules29051186.
In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl--phenyl-1H-pyrazole-3-carboxamide () and 1,5-dimethyl--propyl-1H-pyrazole-3-carboxamide (), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex Ni() () and a dinuclear complex [Cd()]Cl (). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, and present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes and .
在本研究中，我们基于吡唑基配体合成了两种配位络合物，即1,5 - 二甲基 - 苯基 - 1H - 吡唑 - 3 - 甲酰胺（）和1,5 - 二甲基 - 丙基 - 1H - 吡唑 - 3 - 甲酰胺（），旨在研究生物无机性质。它们的晶体结构揭示了一种单核络合物Ni() （）和一种双核络合物[Cd()]Cl （）。与参考标准环己酰亚胺相比，发现它们具有非常强的抗真菌和抗镰刀菌活性。此外，与观察到的配位络合物和的遗传毒性增加相比，和表现出非常弱的遗传毒性。
Zotero 插件