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多环芳烃与胰腺癌:血液生物标志物-1,2,3,4-四羟基-1,2,3,4-四氢菲与部分代谢基因单核苷酸多态性分析。

Polycyclic Aromatic Hydrocarbons and Pancreatic Cancer: An Analysis of the Blood Biomarker, -1,-2,3,-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and Selected Metabolism Gene SNPs.

机构信息

Department of Public Health, North Dakota State University, Fargo, ND 58105, USA.

Fairbanks School of Public Health, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.

出版信息

Nutrients. 2024 Feb 28;16(5):688. doi: 10.3390/nu16050688.

Abstract

Exposure to polycyclic aromatic hydrocarbons (PAHs), byproducts of incomplete combustion, and their effects on the development of cancer are still being evaluated. Recent studies have analyzed the relationship between PAHs and tobacco or dietary intake in the form of processed foods and smoked/well-done meats. This study aims to assess the association of a blood biomarker and metabolite of PAHs, -1,-2,3,-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), dietary intake, selected metabolism SNPs, and pancreatic cancer. Demographics, food-frequency data, SNPs, treatment history, and levels of PheT in plasma were determined from 400 participants (202 cases and 198 controls) and evaluated based on pancreatic adenocarcinoma diagnosis. Demographic and dietary variables were selected based on previously published literature indicating association with pancreatic cancer. A multiple regression model combined the significant demographic and food items with SNPs. Final multivariate logistic regression significant factors (-value < 0.05) associated with pancreatic cancer included: Type 2 Diabetes [OR = 6.26 (95% CI = 2.83, 14.46)], PheT [1.03 (1.02, 1.05)], very well-done red meat [0.90 (0.83, 0.96)], fruit/vegetable servings [1.35 (1.06, 1.73)], recessive (rs12203582) [4.11 (1.77, 9.91)], recessive (rs56679) [0.2 (0.06, 0.85)], overdominant (rs3784605) [3.14 (1.69, 6.01)], and overdominant (rs721430) [0.39 (0.19, 0.76)]. Of note, by design, the level of smoking did not differ between our cases and controls. This study does not provide strong evidence that PheT is a biomarker of pancreatic cancer susceptibility independent of dietary intake and select metabolism SNPs among a nonsmoking population.

摘要

多环芳烃(PAHs)是不完全燃烧的副产品,其暴露及其对癌症发展的影响仍在评估中。最近的研究分析了 PAHs 与烟草或饮食摄入的关系,以加工食品和熏制/熟透肉类的形式摄入。本研究旨在评估血液生物标志物和 PAHs 的代谢物 1,2,3,4-四羟基-1,2,3,4-四氢化菲(PheT)与饮食摄入、选定代谢 SNP 以及胰腺癌之间的关联。从 400 名参与者(202 例病例和 198 例对照)中确定了人口统计学、食物频率数据、SNP、治疗史和血浆中 PheT 的水平,并根据胰腺腺癌的诊断进行了评估。人口统计学和饮食变量是基于先前发表的文献选择的,这些文献表明与胰腺癌有关。一个多元回归模型将显著的人口统计学和食物项目与 SNP 结合起来。与胰腺癌相关的最终多变量逻辑回归显著因素(-值<0.05)包括:2 型糖尿病[比值比(OR)=6.26(95%置信区间(CI)=2.83,14.46)]、PheT[1.03(1.02,1.05)]、非常熟透的红肉[0.90(0.83,0.96)]、水果/蔬菜份数[1.35(1.06,1.73)]、隐性(rs12203582)[4.11(1.77,9.91)]、隐性(rs56679)[0.2(0.06,0.85)]、超显性(rs3784605)[3.14(1.69,6.01)]和超显性(rs721430)[0.39(0.19,0.76)]。值得注意的是,根据设计,我们的病例和对照之间的吸烟水平没有差异。本研究没有提供强有力的证据表明,在非吸烟人群中,PheT 是独立于饮食摄入和特定代谢 SNP 的胰腺癌易感性的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7426/10935191/1ce54752a704/nutrients-16-00688-g001.jpg

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