Jiang Fang-Lin, Jeong Dong-Ho, Eom Seon-Ho, Lee Hae-Moon, Cha Bong-Jin, Park Ju-Seong, Kwon RyoonKyoung, Nam Jeong-Yeon, Yu Hyun-Seon, Heo Su-Hak, Kim Chul-Hyun, Song Keon-Hyoung
National Traditional Sports Teaching and Research Section of Hunan Province, College of Physical Education, Hunan Normal University, Changsha 410012, China.
Department of Pharmaceutical Engineering, College of Medical Sciences, Soonchunhyang University, Asan 31538, Republic of Korea.
Nutrients. 2024 Mar 5;16(5):744. doi: 10.3390/nu16050744.
Sodium bicarbonate is used as an ergogenic supplement to enhance people's performances in various exercises. This study aimed to evaluate the effects of intestinal delivery of sodium bicarbonate on bicarbonate absorption and associated side effects in an experimental human trial. After preparing and assessing enteric-coated and uncoated sodium bicarbonate tablet formulations, pharmacokinetic analysis and gastrointestinal symptom tests were performed after oral administration in the human body. The dose required to increase blood bicarbonate concentration over 5 mmol∙L for the purpose of improving performance during high-intensity exercise was also determined. Enteric-coated tablet formulation protects sodium bicarbonate under acidic conditions and releases bicarbonate in the intestine. Enteric-coated tablet formulation also reduced the oral dose required to achieve a blood bicarbonate concentration over 5 mmol∙L from 300 mg∙kg of uncoated tablet formulation to 225 mg∙kg. Gastrointestinal discomfort was significantly decreased for the group given 225 mg∙kg enteric-coated tablets compared to that given 300 mg∙kg uncoated tablets. These results suggest that enteric-coated tablet formulation could reduce the oral dose required in order to achieve a blood bicarbonate concentration over 5 mmol∙L by 25%, from 300 mg∙kg to 225 mg∙kg, along with its ability to reduce gastrointestinal discomfort associated with the dosage.
碳酸氢钠被用作一种提高体能的补充剂，以增强人们在各种运动中的表现。本研究旨在通过一项人体试验评估肠道给药碳酸氢钠对碳酸氢盐吸收及相关副作用的影响。在制备并评估肠溶包衣和未包衣的碳酸氢钠片剂配方后，在人体口服给药后进行了药代动力学分析和胃肠道症状测试。还确定了为提高高强度运动表现而使血液碳酸氢盐浓度升高超过5 mmol∙L所需的剂量。肠溶包衣片剂配方可在酸性条件下保护碳酸氢钠，并在肠道中释放碳酸氢盐。肠溶包衣片剂配方还将使血液碳酸氢盐浓度升高超过5 mmol∙L所需的口服剂量从未包衣片剂配方的300 mg∙kg降至225 mg∙kg。与给予300 mg∙kg未包衣片剂的组相比，给予225 mg∙kg肠溶包衣片剂的组胃肠道不适明显减轻。这些结果表明，肠溶包衣片剂配方可将使血液碳酸氢盐浓度升高超过5 mmol∙L所需的口服剂量从300 mg∙kg降至225 mg∙kg，降低25%，同时还具有减轻与该剂量相关的胃肠道不适的能力。
