• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过整合生物信息学分析鉴定 LACTB2 在卵巢癌中的预后价值及其与免疫浸润的相关性。

Identification of the prognostic value of LACTB2 and its correlation with immune infiltrates in ovarian cancer by integrated bioinformatics analyses.

机构信息

Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.

Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.

出版信息

Eur J Med Res. 2024 Mar 12;29(1):166. doi: 10.1186/s40001-024-01762-2.

DOI:10.1186/s40001-024-01762-2
PMID:38475882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10929091/
Abstract

Ovarian cancer (OC) is one of the most common reproductive tumors in women, whereas current treatment options are limited. β-lactamase-like-protein 2 (LACTB2) has been observed to be associated with various cancers, but its function in OC is unknown. Therefore, we evaluate the prognostic value and the underlying function of LACTB2 in OC. In this study, high expression of LACTB2 was observed in OC compared with normal controls. Kaplan-Meier Plotter analysis revealed that overexpressed LACTB2 is strongly correlated with poor prognosis. We conducted GO/KEGG analysis to investigate the potential biological function of LACTB2 in OC. GESA analysis showed that LACTB2 was closely related to immune-related pathways. Subsequently, we explored the relationship between LACTB2 and 24 types of immune cells in OC. The results suggested that LACTB2 was positively associated with multiple tumor-infiltrating immune cells. Importantly, LACTB2 may modulate immune cell infiltration in OC to influence prognosis. In conclusion, LACTB2 can be used as a promising prognostic biomarker and immunotherapy target for OC.

摘要

卵巢癌（OC）是女性最常见的生殖系统肿瘤之一，而目前的治疗选择有限。β-内酰胺酶样蛋白 2（LACTB2）已被观察与多种癌症相关，但它在 OC 中的功能尚不清楚。因此，我们评估了 LACTB2 在 OC 中的预后价值和潜在功能。在这项研究中，与正常对照组相比，OC 中观察到 LACTB2 的高表达。Kaplan-Meier Plotter 分析显示，过表达的 LACTB2 与预后不良密切相关。我们进行了 GO/KEGG 分析，以研究 LACTB2 在 OC 中的潜在生物学功能。GESA 分析表明，LACTB2 与免疫相关途径密切相关。随后，我们探索了 LACTB2 与 OC 中 24 种免疫细胞之间的关系。结果表明，LACTB2 与多种肿瘤浸润免疫细胞呈正相关。重要的是，LACTB2 可能调节 OC 中的免疫细胞浸润，从而影响预后。总之，LACTB2 可以作为 OC 有前途的预后生物标志物和免疫治疗靶标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/74d1b8f3d96c/40001_2024_1762_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/c87416b561bd/40001_2024_1762_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/1ca18ec46373/40001_2024_1762_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/86dd3e97b930/40001_2024_1762_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/7f3b12882a95/40001_2024_1762_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/8538aa02b01f/40001_2024_1762_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/996488785251/40001_2024_1762_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/4d98d0df1fea/40001_2024_1762_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/74d1b8f3d96c/40001_2024_1762_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/c87416b561bd/40001_2024_1762_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/1ca18ec46373/40001_2024_1762_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/86dd3e97b930/40001_2024_1762_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/7f3b12882a95/40001_2024_1762_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/8538aa02b01f/40001_2024_1762_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/996488785251/40001_2024_1762_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/4d98d0df1fea/40001_2024_1762_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf9/10929091/74d1b8f3d96c/40001_2024_1762_Fig8_HTML.jpg

相似文献

1
Identification of the prognostic value of LACTB2 and its correlation with immune infiltrates in ovarian cancer by integrated bioinformatics analyses.通过整合生物信息学分析鉴定 LACTB2 在卵巢癌中的预后价值及其与免疫浸润的相关性。
Eur J Med Res. 2024 Mar 12;29(1):166. doi: 10.1186/s40001-024-01762-2.
2
Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis.通过综合生物信息学分析鉴定 MEG8/miR-378d/SOBP 轴作为一个新的调控网络，并与卵巢癌中的免疫浸润相关。
Cancer Med. 2021 Apr;10(8):2924-2939. doi: 10.1002/cam4.3854. Epub 2021 Mar 19.
3
Molecular Analysis of Prognosis and Immune Infiltration of Ovarian Cancer Based on Homeobox D Genes.基于同源盒 D 基因的卵巢癌预后和免疫浸润的分子分析。
Comput Math Methods Med. 2022 Sep 29;2022:3268386. doi: 10.1155/2022/3268386. eCollection 2022.
4
An Integrative Analysis Revealing ZFHX4-AS1 as a Novel Prognostic Biomarker Correlated with Immune Infiltrates in Ovarian Cancer.一项整合分析揭示 ZFHX4-AS1 作为一种新型的与卵巢癌免疫浸润相关的预后生物标志物。
J Immunol Res. 2022 Jun 26;2022:9912732. doi: 10.1155/2022/9912732. eCollection 2022.
5
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer.全面分析层粘连蛋白基因在卵巢癌中的表达和预后。
Pathol Oncol Res. 2021 Aug 25;27:1609855. doi: 10.3389/pore.2021.1609855. eCollection 2021.
6
Identification of an Autophagy-Related Signature for Prognosis and Immunotherapy Response Prediction in Ovarian Cancer.鉴定卵巢癌中与自噬相关的预后和免疫治疗反应预测的标志物。
Biomolecules. 2023 Feb 9;13(2):339. doi: 10.3390/biom13020339.
7
Increased LACTB2 Expression Regulates Oxidative Phosphorylation and mTORC1 Signaling of Colorectal Cancer.LACTB2表达增加调控结直肠癌的氧化磷酸化和mTORC1信号传导
Mol Biotechnol. 2025 Apr;67(4):1539-1555. doi: 10.1007/s12033-024-01137-2. Epub 2024 Apr 25.
8
Role of the KRT7 Biomarker in Immune Infiltration and Paclitaxel Resistance in Ovarian.KRT7 标志物在卵巢癌免疫浸润和紫杉醇耐药中的作用
Altern Ther Health Med. 2023 Jul;29(5):132-140.
9
Comprehensive Analysis of Prognostic Value of MEX3A and Its Relationship with Immune Infiltrates in Ovarian Cancer.全面分析 MEX3A 在卵巢癌中的预后价值及其与免疫浸润的关系。
J Immunol Res. 2021 Jun 3;2021:5574176. doi: 10.1155/2021/5574176. eCollection 2021.
10
Identification and validation of pyroptosis-related gene landscape in prognosis and immunotherapy of ovarian cancer.鉴定和验证卵巢癌预后和免疫治疗中的焦亡相关基因图谱。
J Ovarian Res. 2023 Jan 27;16(1):27. doi: 10.1186/s13048-022-01065-2.

引用本文的文献

1
Integrative multi-omics and machine learning approach reveals tumor microenvironment-associated prognostic biomarkers in ovarian cancer.整合多组学与机器学习方法揭示卵巢癌中与肿瘤微环境相关的预后生物标志物。
Transl Cancer Res. 2024 Nov 30;13(11):6182-6200. doi: 10.21037/tcr-24-539. Epub 2024 Nov 7.

本文引用的文献

1
Th2 cells infiltrating high-grade serous ovarian cancer: a feature that may account for the poor prognosis.浸润在高级别浆液性卵巢癌中的 Th2 细胞：可能是导致不良预后的一个特征。
J Gynecol Oncol. 2023 Jul;34(4):e48. doi: 10.3802/jgo.2023.34.e48. Epub 2023 Mar 23.
2
LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma.LACTB2 通过激活 PINK1/Parkin 依赖性线粒体自噬赋予鼻咽癌放射抵抗性。
Cancer Lett. 2021 Oct 10;518:127-139. doi: 10.1016/j.canlet.2021.07.019. Epub 2021 Jul 13.
3
Defining functional variants associated with Alzheimer's disease in the induced immune response.
在诱导免疫反应中定义与阿尔茨海默病相关的功能变异体。
Brain Commun. 2021 Apr 19;3(2):fcab083. doi: 10.1093/braincomms/fcab083. eCollection 2021.
4
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
5
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.肿瘤诱导 T 细胞从头合成类固醇以逃避免疫。
Nat Commun. 2020 Jul 17;11(1):3588. doi: 10.1038/s41467-020-17339-6.
6
Immunotherapy For Ovarian Cancer: Recent Advances And Combination Therapeutic Approaches.卵巢癌的免疫疗法：最新进展与联合治疗方法
Onco Targets Ther. 2020 Jun 26;13:6109-6129. doi: 10.2147/OTT.S205950. eCollection 2020.
7
CTHRC1 in Ovarian Cancer Promotes M2-Like Polarization of Tumor-Associated Macrophages via Regulation of the STAT6 Signaling Pathway.卵巢癌中的CTHRC1通过调节STAT6信号通路促进肿瘤相关巨噬细胞向M2样极化。
Onco Targets Ther. 2020 Jun 17;13:5743-5753. doi: 10.2147/OTT.S250520. eCollection 2020.
8
TIMER2.0 for analysis of tumor-infiltrating immune cells.TIMER2.0 用于分析肿瘤浸润免疫细胞。
Nucleic Acids Res. 2020 Jul 2;48(W1):W509-W514. doi: 10.1093/nar/gkaa407.
9
Identification of recurrence marker associated with immune infiltration in prostate cancer with radical resection and build prognostic nomogram.鉴定与根治性切除术相关的前列腺癌免疫浸润的复发标志物，并构建预后列线图。
BMC Cancer. 2019 Dec 3;19(1):1179. doi: 10.1186/s12885-019-6391-9.
10
VISTA expression is associated with a favorable prognosis in patients with high-grade serous ovarian cancer.VISTA 表达与高级别浆液性卵巢癌患者的良好预后相关。
Cancer Immunol Immunother. 2020 Jan;69(1):33-42. doi: 10.1007/s00262-019-02434-5. Epub 2019 Nov 28.