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人体皮肤的太赫兹成像：迈向异常皮肤病变的检测

Terahertz imaging of human skin: Toward detection of abnormal skin pathologies.

作者信息

Qi X, Bertling K, Torniainen J, Kong F, Gillespie T, Primiero C, Stark M S, Dean P, Indjin D, Li L H, Linfield E H, Davies A G, Brünig M, Mills T, Rosendahl C, Soyer H P, Rakić A D

机构信息

School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane QLD 4072, Australia.

Dermatology Research Centre, Frazer Institute, The University of Queensland, Woolloongabba QLD 4102, Australia.

出版信息

APL Bioeng. 2024 Mar 11;8(1):016117. doi: 10.1063/5.0190573. eCollection 2024 Mar.

DOI:10.1063/5.0190573
PMID:38476403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10932572/
Abstract

Terahertz (THz) imaging has long held promise for skin cancer detection but has been hampered by the lack of practical technological implementation. In this article, we introduce a technique for discriminating several skin pathologies using a coherent THz confocal system based on a THz quantum cascade laser. High resolution THz images (with diffraction limited to the order of 100 m) of several different lesion types were acquired and compared against one another using the amplitude and phase values. Our system successfully separated pathologies using a combination of phase and amplitude information and their respective surface textures. The large scan field (50 × 40 mm) of the system allows macroscopic visualization of several skin lesions in a single frame. Utilizing THz imaging for dermatological assessment of skin lesions offers substantial additional diagnostic value for clinicians. THz images contain information complementary to the information contained in the conventional digital images.

摘要

太赫兹（THz）成像长期以来一直有望用于皮肤癌检测，但因缺乏实际的技术应用而受到阻碍。在本文中，我们介绍了一种使用基于太赫兹量子级联激光器的相干太赫兹共聚焦系统来鉴别几种皮肤病变的技术。采集了几种不同病变类型的高分辨率太赫兹图像（衍射极限约为100μm），并使用幅度和相位值相互比较。我们的系统通过结合相位和幅度信息及其各自的表面纹理成功地分离了病变。该系统的大扫描场（50×40mm）允许在单帧中对多个皮肤病变进行宏观可视化。利用太赫兹成像对皮肤病变进行皮肤病学评估为临床医生提供了大量额外的诊断价值。太赫兹图像包含与传统数字图像中所含信息互补的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/2a04f06c61f0/ABPID9-000008-016117_1-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/394116966cb7/ABPID9-000008-016117_1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/4271191af7d7/ABPID9-000008-016117_1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/c9f52574a691/ABPID9-000008-016117_1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/d42ce039d682/ABPID9-000008-016117_1-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/ddc1a0fd4782/ABPID9-000008-016117_1-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/6cb469a9b707/ABPID9-000008-016117_1-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/068458f13e5b/ABPID9-000008-016117_1-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/2a04f06c61f0/ABPID9-000008-016117_1-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/394116966cb7/ABPID9-000008-016117_1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/4271191af7d7/ABPID9-000008-016117_1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/c9f52574a691/ABPID9-000008-016117_1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/d42ce039d682/ABPID9-000008-016117_1-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/ddc1a0fd4782/ABPID9-000008-016117_1-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/6cb469a9b707/ABPID9-000008-016117_1-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/068458f13e5b/ABPID9-000008-016117_1-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1631/10932572/2a04f06c61f0/ABPID9-000008-016117_1-g008.jpg

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Coherent terahertz laser feedback interferometry for hydration sensing in leaves.用于叶片水分传感的相干太赫兹激光反馈干涉测量法。
Opt Express. 2023 Jul 17;31(15):23877-23888. doi: 10.1364/OE.490217.
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Comparison of Physical and System Factors Impacting Hydration Sensing in Leaves Using Terahertz Time-Domain and Quantum Cascade Laser Feedback Interferometry Imaging.使用太赫兹时域和量子级联激光反馈干涉成像比较影响叶片水感知的物理和系统因素。
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