Peng Yan, Shi Chenjun, Wu Xu, Zhu Yiming, Zhuang Songlin
Terahertz Technology Innovation Research Institute, Shanghai Key Lab of Modern Optical System, Terahertz Science Cooperative Innovation Center, University of Shanghai for Science and Technology, Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai, China.
BME Front. 2020 Sep 25;2020:2547609. doi: 10.34133/2020/2547609. eCollection 2020.
Terahertz (THz) waves are electromagnetic waves with frequency in the range from 0.1 to 10 THz. THz waves have great potential in the biomedical field, especially in cancer diagnosis, because they exhibit low ionization energy and can be used to discern most biomolecules based on their spectral fingerprints. In this paper, we review the recent progress in two applications of THz waves in cancer diagnosis: imaging and spectroscopy. THz imaging is expected to help researchers and doctors attain a direct intuitive understanding of a cancerous area. THz spectroscopy is an efficient tool for component analysis of tissue samples to identify cancer biomarkers. Additionally, the advantages and disadvantages of the developed technologies for cancer diagnosis are discussed. Furthermore, auxiliary techniques that have been used to enhance the spectral signal-to-noise ratio (SNR) are also reviewed.
太赫兹（THz）波是频率范围在0.1至10太赫兹之间的电磁波。太赫兹波在生物医学领域具有巨大潜力，尤其是在癌症诊断方面，因为它们具有低电离能，并且可用于根据大多数生物分子的光谱指纹来辨别它们。在本文中，我们综述了太赫兹波在癌症诊断中的两种应用的最新进展：成像和光谱学。太赫兹成像有望帮助研究人员和医生直接直观地了解癌区。太赫兹光谱学是用于组织样本成分分析以识别癌症生物标志物的有效工具。此外，还讨论了已开发的癌症诊断技术的优缺点。此外，还综述了用于提高光谱信噪比（SNR）的辅助技术。
