Sinha Sharmili, Paul Gunchan, Shah Bhagyesh A, Karmata Tejas, Paliwal Naveen, Dobariya Jayesh, Srikant Behera, Mona Aarti, Thakkar Vipul P, Padhi Gunadhar, Bihani Pooja, Karmakar Saurabh, Prakash Jay, Rath Mayurdhwaja, Mishra Anand, Singhal Vinay, Ruparelia Alpesh, Chaudhury Alisha, Goyal Alaukik
Department of Critical Care Medicine, Apollo Hospitals, Bhubaneswar, Odisha, India.
Department of Critical Care Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Indian J Crit Care Med. 2024 Mar;28(3):265-272. doi: 10.5005/jp-journals-10071-24656.
The aim was to examine the outcomes of pregnant women admitted to intensive care unit with coronavirus disease-2019 (COVID-19) infection during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in India. The primary outcome of the study was maternal mortality at day 30. The secondary outcomes were the intensive care unit (ICU) and hospital length of stay, fetal mortality and preterm delivery.
This was a retrospective multicentric cohort study. Ethical clearance was obtained. All pregnant women of the 15-45-year age admitted to ICUs with SARS-CoV-2 infection during 1st March 2020 to 31st October, 2021 were included.
Data were collected from nine centers and for 211 obstetric patients admitted to the ICU with a confirmed diagnosis of COVID-19. They were divided in to two groups as per their SpO (saturation of peripheral oxygen) level at admission on room air, that is, normal SpO group (SpO > 90%) and low SpO group (SpO < 90%). The mean age was (30.06 ± 4.25) years and the gestational age was 36 ± 8 weeks. The maternal mortality rate was10.53%. The rate of fetal death and preterm delivery was 7.17 and 28.22%, respectively. The average ICU and hospital length of stay (LOS) were 6.35 ± 8.56 and 6.78 ± 6.04 days, respectively. The maternal mortality (6.21 vs 43.48%, < 0.001), preterm delivery (26.55 vs 52.17%, = 0.011) and fetal death (5.08 vs 26.09%, = 0.003) were significantly higher in the low SpO group.
The overall maternal mortality among critically ill pregnant women affected with COVID-19 infection was 10.53%. The rate of preterm birth and fetal death were 28.22 and 7.17%, respectively. These adverse maternal and fetal outcomes were significantly higher in those admitted with low SpO (<90%) at admission compared with those with normal SpO.
Sinha S, Paul G, Shah BA, Karmata T, Paliwal N, Dobariya J, . Retrospective Analysis of Clinical Characteristics and Outcomes of Pregnant Women with SARS-CoV-2 Infections Admitted to Intensive Care Units in India (Preg-CoV): A Multicenter Study. Indian J Crit Care Med 2024;28(3):265-272.
本研究旨在调查在印度严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行期间，因感染2019冠状病毒病（COVID-19）而入住重症监护病房的孕妇的结局。本研究的主要结局是第30天的孕产妇死亡率。次要结局包括重症监护病房（ICU）住院时间、医院住院时间、胎儿死亡率和早产。
这是一项回顾性多中心队列研究。已获得伦理批准。纳入了2020年3月1日至2021年10月31日期间因SARS-CoV-2感染入住ICU的所有15至45岁的孕妇。
数据来自9个中心，共211例确诊为COVID-19的产科患者入住ICU。根据她们在室内空气中入院时的外周血氧饱和度（SpO）水平，将她们分为两组，即正常SpO组（SpO>90%）和低SpO组（SpO<90%）。平均年龄为（30.06±4.25）岁，孕周为36±8周。孕产妇死亡率为10.53%。胎儿死亡和早产率分别为7.17%和28.22%。ICU平均住院时间和医院住院时间分别为6.35±8.56天和6.78±6.04天。低SpO组的孕产妇死亡率（6.21%对43.48%，P<0.001）、早产率（分别为26.55%对52.17%，P=0.011）和胎儿死亡率（分别为5.08%对26.09%，P=0.003）显著更高。
感染COVID-19的重症孕妇的总体孕产妇死亡率为10.53%。早产率和胎儿死亡率分别为28.22%和7.17%。与SpO正常的孕妇相比，入院时SpO低（<90%）的孕妇的这些不良母婴结局显著更高。
Sinha S, Paul G, Shah BA, Karmata T, Paliwal N, Dobariya J, 。印度入住重症监护病房的SARS-CoV-2感染孕妇的临床特征和结局的回顾性分析（Preg-CoV）：一项多中心研究。《印度重症监护医学杂志》2024；28（3）：265-272。
