Khoronenko V E, Trifanov V S, Chebotareva N V, Meshcheryakova M Yu, Kosogolov M V
Hertsen Moscow Oncology Research Institute, Moscow, Russia.
Sechenov First Moscow State Medical University, Moscow, Russia.
Khirurgiia (Mosk). 2024(3):76-82. doi: 10.17116/hirurgia202403176.
McKittrick-Wheelock syndrome is a rare disease when villous adenoma of the distal colon predisposes to profuse watery diarrhea with subsequent severe electrolyte disturbances and acute renal damage. A differentiated approach to correct diagnosis requires in-depth pathophysiological knowledge of regulation of water-electrolyte metabolism, functional and organic disorders of gastrointestinal tract and clinical manifestations of hypoosmolar dehydration. The peculiarity of the McKittrick-Wheelock syndrome is a 100% probability of death without treatment and complete regression of symptoms under complex correction of homeostasis and total resection of tumor. We demonstrate the main clinical trends of the McKittrick-Wheelock syndrome. This report may be useful for general practitioners, gastroenterologists, oncologists, nephrologists and anesthesiologists.
麦基特里克 - 惠洛克综合征是一种罕见疾病，远端结肠绒毛状腺瘤易引发大量水样腹泻，继而导致严重的电解质紊乱和急性肾损伤。正确诊断需要采用差异化方法，这需要深入了解水电解质代谢调节、胃肠道功能和器质性疾病以及低渗性脱水的临床表现等病理生理学知识。麦基特里克 - 惠洛克综合征的特点是未经治疗时死亡概率为100%，而在进行内环境稳态的综合纠正和肿瘤全切除术后症状可完全消退。我们展示了麦基特里克 - 惠洛克综合征的主要临床趋势。本报告可能对全科医生、胃肠病学家、肿瘤学家、肾病学家和麻醉学家有用。
