Morden Research and Development Centre, Agriculture and Agri-Food Canada, Morden, MB R6M 1Y5, Canada.
Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB R2H 2A6, Canada.
Appl Physiol Nutr Metab. 2024 Jun 1;49(6):738-750. doi: 10.1139/apnm-2023-0440. Epub 2024 Mar 13.
Oats are recognized to provide many health benefits that are mainly associated with its dietary fibre, β-glucan. However, the protein derived from oats is largely understudied with respect to its ability to maintain health and attenuate risk factors of chronic diseases. The goal of the current study was to investigate the metabolic effects of oat protein consumption in lieu of casein as the protein source in high fat, high sucrose (HF/HS) fed Wistar rats. Four-week-old rats were divided into three groups and were fed three different experimental diets: a control diet with casein as the protein source, an HF/HS diet with casein, or an HF/HS diet with oat protein for 16 weeks. Heart structure and function were determined by echocardiography. Blood pressure measurements, an oral glucose tolerance test, and markers of cholesterol metabolism, oxidative stress, inflammation, and liver and kidney damage were also performed. Our study results show that incorporation of oat protein in the diet was effective in preserving systolic heart function in HF/HS fed rats. Oat protein significantly reduced serum total and low-density lipoprotein cholesterol levels. Furthermore, oat protein normalized liver HMG-CoAR activity, which, to our knowledge, is the first time this has been reported in the literature. Therefore, our research suggests that oat protein can provide hypocholesterolemic and cardioprotective benefits in a diet-induced model of metabolic syndrome.
燕麦被认为具有许多健康益处，这些益处主要与其膳食纤维β-葡聚糖有关。然而，燕麦蛋白作为一种蛋白质来源，其对维持健康和减轻慢性病风险因素的能力在很大程度上还没有得到研究。本研究的目的是研究以燕麦蛋白替代酪蛋白作为高脂肪、高蔗糖（HF/HS）喂养 Wistar 大鼠的蛋白质来源时的代谢效应。将 4 周龄大鼠分为三组，并分别用三种不同的实验饮食喂养：以酪蛋白为蛋白质来源的对照饮食、以酪蛋白为蛋白质来源的 HF/HS 饮食或以燕麦蛋白为蛋白质来源的 HF/HS 饮食喂养 16 周。通过超声心动图测定心脏结构和功能。还进行了血压测量、口服葡萄糖耐量试验以及胆固醇代谢、氧化应激、炎症和肝肾功能损伤的标志物检测。我们的研究结果表明，在 HF/HS 喂养的大鼠饮食中添加燕麦蛋白可有效维持收缩期心脏功能。燕麦蛋白显著降低了血清总胆固醇和低密度脂蛋白胆固醇水平。此外，燕麦蛋白使肝脏 HMG-CoAR 活性正常化，据我们所知，这是文献中首次报道。因此，我们的研究表明，燕麦蛋白可以在代谢综合征的饮食诱导模型中提供降胆固醇和心脏保护作用。
