艾滋病毒血清阳性和血清阴性队列中饮酒与血压水平之间的关联：Vukuzazzi 研究的二次分析。
Association Between Alcohol Consumption and Blood Pressure Levels Among HIV Sero-Positive and Sero-Negative Cohorts: A Secondary Analysis of the Vukuzazzi Study.
机构信息
Department of Applied and Theoretical Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Physiology and Environmental Health, University of Limpopo, South Africa.
出版信息
J Prim Care Community Health. 2024 Jan-Dec;15:21501319241235594. doi: 10.1177/21501319241235594.
BACKGROUND
The effect of hypertension is aggravated by lifestyle factors such as alcohol consumption. This study sought to determine the association between alcohol consumption and the level of blood pressures among HIV seronegative and seropositive cohorts.
METHODS
This secondary analysis was performed on a cross-sectional survey data of 17 922 participants during the period between 2018 and 2020. A questionnaire was used to obtain participants' alcohol consumption history, which was categorized into non-alcohol consumers, non-heavy alcohol consumers, and heavy alcohol consumers. A linear regression model was used to establish relationships among participants with raised blood pressure (BP ≥ 140/90 mmHg).
RESULTS
Out of the total participants, 3553 (19.82%) were hypertensives. Almost 13% of the hypertensives (n = 458; 12.89%) were undiagnosed, and 12.44 % (442) had uncontrolled hypertension. About 14.52% of the hypertensives (3553) were not on any antihypertensive medication. Male non-consumers of alcohol had the highest systolic and diastolic BP; uncontrolled systolic BP (165.53 ± 20.87 mmHg), uncontrolled diastolic BP (102.28 ± 19.21mmHg). Adjusted for covariates, moderate alcohol consumption was associated with HTN among participants who were HIV seropositive [unadjusted (RR = 1.772, = .006, 95% CI (1.178-2.665)], [RR = 1.772, = .005, 95% CI (1.187-2.64)]. [unadjusted RR = 1.876, = .036, 95% CI (1.043-3.378)], adjusted RR = 1.876, = .041, 95% CI (1.024-3.437). Both moderate and heavy alcohol consumption were significantly related to hypertension among HIV sero-negative [unadjusted model, moderate consumption RR = 1.534 = .003, 95% CI (1.152-2.044)], [adjusted model, moderate alcohol consumption RR = 1.535, = .006, 95% CI (1.132-2.080)], [unadjusted model, heavy alcohol consumption, RR = 2.480, = .030, 95% CI (1.091-5.638)], [adjusted model RR = 2.480, = .034, 95% CI (1.072-5.738)].
CONCLUSION
Alcohol consumption is significantly related to increase BP regardless of HIV infection.
背景
高血压的影响会因饮酒等生活方式因素而加重。本研究旨在确定饮酒与 HIV 血清阴性和阳性队列的血压水平之间的关系。
方法
这是对 2018 年至 2020 年期间进行的横断面调查数据的二次分析，共有 17922 名参与者。使用问卷获得参与者的饮酒史，分为非饮酒者、非重度饮酒者和重度饮酒者。使用线性回归模型建立与血压升高（BP≥140/90mmHg）有关的参与者之间的关系。
结果
在总参与者中，3553 人（19.82%）患有高血压。几乎 13%的高血压患者（n=458；12.89%）未被诊断出，12.44%（442 人）血压控制不佳。大约 14.52%的高血压患者（3553 人）没有服用任何降压药物。男性非饮酒者的收缩压和舒张压最高；未控制的收缩压（165.53±20.87mmHg）、未控制的舒张压（102.28±19.21mmHg）。调整协变量后，中度饮酒与 HIV 血清阳性者的 HTN 相关[未调整（RR=1.772，=0.006，95%CI（1.178-2.665）]，[RR=1.772，=0.005，95%CI（1.187-2.64）]。[未调整 RR=1.876，=0.036，95%CI（1.043-3.378）]，调整后 RR=1.876，=0.041，95%CI（1.024-3.437）]。中度和重度饮酒与 HIV 血清阴性者的高血压显著相关[未调整模型，中度饮酒 RR=1.534=0.003，95%CI（1.152-2.044）]，[调整模型，中度酒精消耗 RR=1.535，=0.006，95%CI（1.132-2.080）]，[未调整模型，重度饮酒 RR=2.480，=0.030，95%CI（1.091-5.638）]，[调整模型 RR=2.480，=0.034，95%CI（1.072-5.738）]。
结论
无论是否感染 HIV，饮酒均与血压升高显著相关。
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