Wake Forest University School of Medicine, Winston-Salem, North Carolina.
University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
Am J Respir Crit Care Med. 2024 Jun 1;209(11):1304-1313. doi: 10.1164/rccm.202311-2130WS.
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairments are not yet well understood, and evidence-based interventions to minimize the burden on patients remain unproved. The NHLBI of the NIH assembled a workshop in April 2023 to review the state of the science regarding ARDS-associated brain and muscle dysfunction, to identify gaps in current knowledge, and to determine priorities for future investigation. The workshop included presentations by scientific leaders across the translational science spectrum and was open to the public as well as the scientific community. This report describes the themes discussed at the workshop as well as recommendations to advance the field toward the goal of improving the health and well-being of ARDS survivors.
急性呼吸窘迫综合征（ARDS）与脑和肌肉功能的长期损伤有关，这些损伤严重影响了那些从急性疾病中存活下来的人的生活质量。这些损伤的机制尚不清楚，也没有经过验证的循证干预措施来减轻患者的负担。美国国立卫生研究院的 NHLBI 于 2023 年 4 月组织了一次研讨会，旨在审查与 ARDS 相关的脑和肌肉功能障碍的科学现状，确定当前知识的差距，并确定未来研究的优先事项。研讨会邀请了跨转化科学领域的科学领导人进行演讲，向公众和科学界开放。本报告描述了研讨会讨论的主题以及为推动该领域发展以实现改善 ARDS 幸存者健康和福祉的目标而提出的建议。
