EZH2 在多形性腺瘤和腺样囊性癌中的免疫表达与临床病理特征。
EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features.
机构信息
Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.
University of Michigan, School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, USA.
出版信息
Braz Oral Res. 2024 Mar 11;38:e018. doi: 10.1590/1807-3107bor-2024.vol38.0018. eCollection 2024.
The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy.
本研究旨在评估 EZH2 蛋白的表达，并描述腺样囊性癌 (ACC) 和多形性腺瘤 (PA) 的临床和显微镜特征。研究纳入 16 例 ACC 病例和 12 例 PA。所有 ACC 和 PA 病例均为 EZH2 阳性，且 ACC 样本中 EZH2 的表达显著更高。对 ACC 样本中 EZH2 染色与临床和显微镜变量的关系进行了描述。在局部转移、复发、神经周围侵犯以及无实性区为主的筛状生长模式的病例中，EZH2 的平均值最高。EZH2 是一种潜在的恶性标志物。
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