Department of Dermatology, Venereology and Aesthetics, Medical Faculty of Sriwijaya University, Dr Mohammad Hoesin General Hospital, Palembang, Indonesia.
Medical Faculty of Sriwijaya University, Palembang, Indonesia.
Int J STD AIDS. 2024 Jun;35(7):543-549. doi: 10.1177/09564624241239102. Epub 2024 Mar 13.
Syphilis infection can be asymptomatic and difficult to diagnose based on clinical symptoms. Early detection and treatment are critical for preventing and controlling syphilis as well as long-term serious complications. A serological examination based on the diagnostic algorithm was used to confirm the diagnosis of syphilis. Syphilis is frequent in high-risk groups, such as men who have sex with men (MSM). (TP) rapid can be used for early syphilis detection. The diagnostic value of TP rapid with diagnostic algorithm (RPR-TPHA) utilizing whole blood in MSM should be studied.
To determine the diagnostic value of TP rapid syphilis test compared to a diagnostic algorithm (RPR-TPHA) among MSM.
A diagnostic test with a cross-sectional design at Dr Mohammad Hoesin Palembang General Hospital from November 2022 to January 2023. The sampling method was consecutive sampling with a total sample of 83 MSM based on inclusion and exclusion criteria. All samples were tested for RPR, TPHA, and TP rapid. The diagnostic value of TP rapid was evaluated with RPR-TPHA as a diagnostic algorithm for syphilis.
The sensitivity and specificity value of the TP rapid compare diagnostic algorithm as gold standard were 95.8% and 96.6% respectively. Other metrics: positive predictive value (PPV) 92%, negative predictive value (NPV) 98%, positive likelihood ratio (PLR) 28.27, negative likelihood ratio (NLR) 0.04, accuracy 96% and AUC 0.962.
The TP rapid test has a high diagnostic value and can be used to establish an early diagnosis of syphilis in MSM.
梅毒感染可能无症状，基于临床症状难以诊断。早期发现和治疗对于预防和控制梅毒以及长期严重并发症至关重要。采用基于诊断算法的血清学检查来确诊梅毒。梅毒在高危人群中较为常见，如男男性行为者（MSM）。（TP）快速检测可用于早期梅毒检测。应研究 RPR-TPHA 诊断算法中利用全血的 MSM 中 TP 快速检测的诊断价值。
确定 TP 快速梅毒检测与 MSM 中的诊断算法（RPR-TPHA）相比的诊断价值。
2022 年 11 月至 2023 年 1 月在巴邻旁穆罕默德·胡辛综合医院进行了一项横断面设计的诊断性试验。采用连续抽样法，根据纳入和排除标准，共选取 83 名 MSM 作为样本。所有样本均接受 RPR、TPHA 和 TP 快速检测。采用 RPR-TPHA 作为梅毒诊断算法评估 TP 快速检测的诊断价值。
TP 快速检测与金标准 RPR-TPHA 比较的灵敏度和特异度值分别为 95.8%和 96.6%。其他指标：阳性预测值（PPV）92%，阴性预测值（NPV）98%，阳性似然比（PLR）28.27，阴性似然比（NLR）0.04，准确度 96%和 AUC 0.962。
TP 快速检测具有较高的诊断价值，可用于建立 MSM 中梅毒的早期诊断。
