Peking University First Hospital, Beijing, China.
Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China.
BMJ Open Respir Res. 2024 Mar 13;11(1):e001699. doi: 10.1136/bmjresp-2023-001699.
No studies have investigated whether high-sensitivity C reactive protein (hsCRP) can be used to predict the forced expiratory volume in 1 s (FEV1)/estimated value of FEV1 (FEV1%pred). This study aimed to assess the association between hsCRP and FEV1%pred in middle-aged and elderly individuals without underlying lung disease.
The data for this study were obtained from a prospective cohort study that included 1047 middle-aged and elderly citizens from Beijing aged 40-75 years without any evidence of underlying lung diseases with FEV1 >70% after receiving inhalational bronchodilators. The baseline analysis of the participants was performed from 30 May 2018 to 31 October 2018. Restricted cubic spline regression and multivariate linear regression models were used to assess the non-linear association and linear association between hsCRP and FEV1/FEV in 6 s (FEV6) and FEV1%pred, respectively.
The hsCRP values of 851 participants were recorded; the values were normal in 713 (83.8%) participants. The remaining 196 participants (18.7%) had missing data. A non-linear association was observed between normal hsCRP values and FEV1/FEV6. hsCRP was linearly and negatively correlated with FEV1%pred, and each 1 SD increase in hsCRP was significantly associated with a 2.4% lower in FEV1%pred. Significantly higher FEV1/FEV6 differences were observed in the female subgroup than those in the male subgroup (p=0.011 for interaction).
hsCRP had a non-linear association with FEV1/FEV6 and a linear negative association with FEV1%pred in individuals with normal hsCRP values. hsCRP can be used to predict FEV1%pred, which can be used to predict the development of chronic obstructive pulmonary disease. hsCRP has a stronger association with lung function in women than that in men.
NCT03532893.
尚无研究探讨高敏 C 反应蛋白（hsCRP）是否可用于预测 1 秒用力呼气容积（FEV1）/预计 FEV1 值（FEV1%pred）。本研究旨在评估无潜在肺部疾病的中老年人群中 hsCRP 与 FEV1%pred 之间的相关性。
本研究的数据来自一项前瞻性队列研究，该研究纳入了来自北京的 1047 名年龄在 40-75 岁之间、使用吸入性支气管扩张剂后 FEV1＞70%且无潜在肺部疾病证据的中老年市民。于 2018 年 5 月 30 日至 10 月 31 日对参与者进行了基线分析。采用限制性立方样条回归和多元线性回归模型分别评估 hsCRP 与 FEV1/FEV6 和 FEV1%pred 之间的非线性和线性关系。
记录了 851 名参与者的 hsCRP 值；713 名（83.8%）参与者的 hsCRP 值正常，其余 196 名（18.7%）参与者的数据缺失。hsCRP 值与 FEV1/FEV6 之间呈非线性关系。hsCRP 与 FEV1%pred 呈线性负相关，hsCRP 每增加 1 个标准差，FEV1%pred 降低 2.4%。女性亚组的 FEV1/FEV6 差值显著高于男性亚组（交互作用 p=0.011）。
hsCRP 与 FEV1/FEV6 呈非线性关系，与 hsCRP 值正常者的 FEV1%pred 呈线性负相关。hsCRP 可用于预测 FEV1%pred，进而预测慢性阻塞性肺疾病的发生。hsCRP 与女性的肺功能相关性强于男性。
NCT03532893。
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