Department of Neonatology, AlWakra hospital, Hamad Medical Corporation, Doha, Qatar.
J Perinatol. 2024 Jul;44(7):1035-1041. doi: 10.1038/s41372-024-01927-1. Epub 2024 Mar 13.
Glucose-6-phosphate dehydrogenase deficiency (G6PDD) being highly prevalent in the Middle East, the primary objective was to estimate the incidence of neonatal jaundice among G6PD-deficient neonates and to explore its association with various risk factors.
This retrospective cohort study includes 7 years data of neonates diagnosed with G6PDD between 1st January 2015, and 30 September 2022, from Al Wakra Hospital, HMC Qatar.
Among the 40,305 total births, 1013 had G6PDD with an incidence of 2.51%. Of all the G6PDD babies, 24.6% (249/1013) received phototherapy and three babies required exchange transfusion. Statistically significant associations were noted between the need for phototherapy and gestational age, gestational age groups, birth weight, and birth weight groups, but logistic regression analysis showed significant association for phototherapy only with the gestational age group.
Universal screening and proper follow-up is essential for G6PDD as it plays crucial role in neonatal jaundice.
葡萄糖-6-磷酸脱氢酶缺乏症（G6PDD）在中东地区高发，因此本研究的主要目的是评估 G6PD 缺乏的新生儿黄疸的发生率，并探讨其与各种危险因素的关系。
这是一项回顾性队列研究，纳入了 2015 年 1 月 1 日至 2022 年 9 月 30 日在卡塔尔哈马德医疗城的 Al Wakra 医院诊断为 G6PDD 的新生儿 7 年的数据。
在 40305 例总分娩中，有 1013 例患有 G6PDD，发病率为 2.51%。在所有患有 G6PDD 的婴儿中，24.6%（249/1013）接受了光疗，有 3 例婴儿需要换血治疗。需要光疗与胎龄、胎龄组、出生体重和出生体重组之间存在统计学显著关联，但 logistic 回归分析显示仅与胎龄组有显著关联。
G6PDD 新生儿需要进行普遍筛查和适当随访，因为它在新生儿黄疸中起着至关重要的作用。
