Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238 Jingshi East Road, Jinan, Shandong, China.
Graduate Department of Shandong First Medical University & Shandong Academy of Medical Sciences, No. 6699 Qingdao Road, Jinan, Shandong, China.
Sci Rep. 2024 Mar 13;14(1):6121. doi: 10.1038/s41598-024-56720-z.
Ischaemic bowel disease (ICBD) is a group of intestinal ischaemia syndromes caused by various aetiologies of reduced intestinal blood flow or vascular occlusion. ICBD can present as abdominal pain, bloody stool, and diarrhoea. This disease often occurs in middle-aged and elderly individuals with cardiovascular and cerebrovascular diseases. The incidence of ischaemic bowel disease has been increasing for decades, and it is difficult to diagnose, resulting in rapid disease progression and a high mortality rate. Therefore, fully understanding this disease, improving the diagnosis rate of this disease, and finding appropriate treatment methods are urgently needed to improve the condition and prognosis of patients. Umbilical cord blood stem cells are accessible, have weak immunogenicity, and have various biological functions, such as angiogenesis, inflammation and immune regulation. Many studies have confirmed that cord blood stem cells can relieve ischaemia, and these cells have attracted tremendous amounts of attention in regenerative medicine in recent years. In this paper, we discuss the clinical characteristics of ICBD, analyse the characteristics of human umbilical cord blood mononuclear cells (HUCB-MNCs), and use its to treat ischaemic bowel disease. Additionally, we compare the clinical manifestations and related indicators before and after treatment to evaluate the efficacy and safety of these methods.
缺血性肠病(ICBD)是一组由各种原因引起的肠道血液减少或血管阻塞引起的肠道缺血综合征。ICBD 可表现为腹痛、血便和腹泻。这种疾病常发生在有心血管和脑血管疾病的中老年人群中。缺血性肠病的发病率在几十年来一直在上升,而且难以诊断,导致疾病迅速进展和高死亡率。因此,充分了解这种疾病,提高这种疾病的诊断率,并找到合适的治疗方法,对于改善患者的病情和预后是非常迫切需要的。脐带血干细胞易于获取,免疫原性较弱,具有多种生物学功能,如血管生成、炎症和免疫调节。许多研究证实脐带血干细胞可以缓解缺血,这些细胞近年来在再生医学中引起了极大的关注。本文讨论了 ICBD 的临床特征,分析了人脐带血单个核细胞(HUCB-MNC)的特征,并将其用于治疗缺血性肠病。此外,我们比较了治疗前后的临床表现和相关指标,以评估这些方法的疗效和安全性。