人脐带血单个核细胞移植治疗围生期脑损伤。
Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury.
机构信息
Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
出版信息
Stem Cell Res Ther. 2022 Sep 5;13(1):458. doi: 10.1186/s13287-022-03153-y.
Abstract
Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on. Human umbilical cord blood mononuclear cells have many biological functions, such as nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune regulation. Human umbilical cord blood mononuclear cells transplantation has achieved significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury. We will review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury in this review.
摘要
围生期脑损伤是儿童死亡和残疾的主要原因。足月婴儿的缺氧缺血性脑病和早产儿的脑白质损伤是围生期最常见的脑损伤。人脐带血单个核细胞包含造血干细胞、间充质干细胞、内皮祖细胞、淋巴细胞、单核细胞等。人脐带血单个核细胞具有神经和血管再生、抗细胞凋亡、抗炎和免疫调节等多种生物学功能。人脐带血单个核细胞移植在动物和临床试验中治疗围生期脑损伤已取得显著疗效和安全性。我们将在本综述中回顾人脐带血单个核细胞移植治疗围生期脑损伤的相关研究。
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