Friedman M J, Roth E F, Nagel R L, Trager W
Am J Trop Med Hyg. 1979 Sep;28(5):777-80.
The host cell competence of hemoglobin C (HbC)-containing erythrocytes for Plasmodium falciparum was studied by in vitro culture. HbC homozygous red cells did not support the growth of the intracellular parasite. Heterozygous cells, however, were competent. In addition, HbC increased the resistance of sicle cell hemoglobin (HbS) red cells when present in the double heterozygote, SC, cultured at low oxygen tension. This effect most likely resulted from the ability of HbC to enhance the sickling of HbS-containing red cells. Oxygenated SC cells were indistinguishable from normal and AS cells in host cell competence. Another double heterozygote, SNBalt, showed decreased sickling and decreased resistance to malaria parasite growth. The evolutionary significance of these results is discussed.
通过体外培养研究了含血红蛋白C（HbC）的红细胞对恶性疟原虫的宿主细胞能力。HbC纯合红细胞不支持细胞内寄生虫的生长。然而，杂合细胞具有这种能力。此外，当HbC存在于双杂合子SC中并在低氧张力下培养时，它会增加镰状细胞血红蛋白（HbS）红细胞的抗性。这种效应很可能是由于HbC增强含HbS红细胞镰变的能力。在宿主细胞能力方面，氧合的SC细胞与正常细胞和AS细胞没有区别。另一种双杂合子SNBalt表现出镰变减少和对疟原虫生长的抗性降低。讨论了这些结果的进化意义。
