Wen Ruishan, Huang Xiulian, Long Jinyu, Guo Yuxin, Wei Yilun, Lin Ping, Xie Siting, Zhao Zhongquan, Zhang Lei, Fan Arthur Yin, Barbalho Sandra M, Nardone Valerio, Alzeer Jawad, Chen Ying, Yu Zongyang
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China.
Transl Cancer Res. 2024 Feb 29;13(2):1166-1187. doi: 10.21037/tcr-23-1983. Epub 2024 Jan 24.
The cancer-immunity cycle (CIC) is defined as a series of progressive events that cause an anticancer immune response leading to the killing of the cancer cell. The concept of CIC has important guiding significance for the clinical and basic tumor immunotherapy research. As one of the methods of traditional Chinese medicine (TCM), Chinese herbal medicine (CHM) has shown unique advantages in multitarget and multipathway immune regulation. However, the tumor immune circulation targeted by CHM is generally unclear at present. To provide reference for future clinical and basic research, we systematically reviewed the existing literature on CHM (including CHM monomers, CHM compounds, and CHM patent medicines) and the mechanisms related to its efficacy.
We searched the PubMed and China National Knowledge Infrastructure (CNKI) databases for relevant Chinese-language and English-language literature published from January 1988 to October 2022. The literature was screened manually at three levels: title, abstract, and full text, to identify articles related to CHM and their mechanism of regulating tumor immunity.
By further classifying the CIC, it was confirmed that CHM can regulate the activation of dendritic cells (DCs) and macrophages and promote the presentation of tumor antigens. Meanwhile, CHM can also reverse tumor-immune escape by enhancing T-cell proliferation and infiltration. In addition, CHM can also enhance the antitumor ability of the body by regulating the killing process of tumor cells.
The theory of a CIC is of guiding significance to regulating tumor immunity via CHM.
癌症免疫循环（CIC）被定义为一系列导致抗癌免疫反应并最终杀死癌细胞的渐进性事件。CIC的概念对临床和基础肿瘤免疫治疗研究具有重要的指导意义。作为中医的方法之一，中草药（CHM）在多靶点和多途径免疫调节方面显示出独特优势。然而，目前CHM所靶向的肿瘤免疫循环总体尚不清楚。为给未来的临床和基础研究提供参考，我们系统回顾了关于CHM（包括CHM单体、CHM化合物和CHM专利药物）及其疗效相关机制的现有文献。
我们在PubMed和中国知网（CNKI）数据库中检索了1988年1月至2022年10月发表的相关中英文文献。通过标题、摘要和全文三个层面进行人工筛选，以确定与CHM及其调节肿瘤免疫机制相关的文章。
通过对CIC进一步分类，证实CHM可调节树突状细胞（DCs）和巨噬细胞的活化，促进肿瘤抗原呈递。同时，CHM还可通过增强T细胞增殖和浸润来逆转肿瘤免疫逃逸。此外，CHM还可通过调节肿瘤细胞的杀伤过程来增强机体的抗肿瘤能力。
CIC理论对通过CHM调节肿瘤免疫具有指导意义。
