Department of Radiology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China.
Medical 3D Printing Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China.
Calcif Tissue Int. 2024 Apr;114(4):397-408. doi: 10.1007/s00223-024-01185-5. Epub 2024 Mar 14.
To investigate the difference in vertebral morphology and bone mineral density (BMD) between grade 1 VFs and non-fractured participants in the Chinese population to shed light on the clinical significance of grade 1 VFs from various perspectives.
This retrospective cohort study included patients who received a chest low-dose computed tomography (LDCT) scan for health examination and visited the First Affiliated Hospital of Zhengzhou University, Henan, China, from October 2019 to August 2022. Data were analyzed from March 2023 to July 2023. The main outcome of this study was the difference in morphological parameters and BMD between grade 1 VFs and non-fractured participants. The prevalence of grade 1 VFs in China populations was calculated. The difference in BMD of three fracture types in the Grade 1 group was also evaluated.
A total of 3652 participants (1799 males, 54.85 ± 9.02 years, range, 40-92 years; 1853 females, 56.00 ± 9.08 years, range, 40-93 years) were included. The prevalence of grade 2 and 3 increase with age. The prevalence of grade 1 VFs gradually increases ≤ 50y to 60-69y group, but there is a decrease in the ≥ 70 years male group (6.6%) and a rise in the female group (25.5%). There was no significant statistical difference observed in vertebral shape indices (VSI) and BMD between the Grade 1 group and the no-fractured group aged < 50 years old except the wedge index in male. The biconcavity index did not differ between the non-fractured group and the Grade 1 group in men aged 50-59 years, whereas a significant statistical difference was observed in women. Additionally, the results of BMD were consistent with these findings. For the 40-59 years age group, there were significant differences between the compression deformity group and the other groups.
The grade 1 group had higher VSI and lower BMD than the non-fractured group, suggesting an association between the Grade 1 group and osteoporosis in individuals aged over 50 for women and over 60 for men. Different fracture types have significant variations in BMD among middle-aged people. The prevalence of grade 1 VFs exhibits an age-related increase in both genders, with opposite trends observed between older males and females. We suggested VSI can aid physicians in the diagnosis of grade 1 VFs.
探讨中国人群中 1 级椎体骨折（VF）与非骨折参与者之间的椎体形态和骨密度（BMD）差异，从不同角度阐明 1 级 VF 的临床意义。
这是一项回顾性队列研究，纳入了 2019 年 10 月至 2022 年 8 月期间在中国郑州大学第一附属医院接受胸部低剂量计算机断层扫描（LDCT）体检的患者。数据于 2023 年 3 月至 7 月进行分析。本研究的主要结局为 1 级 VF 组与非骨折组之间形态参数和 BMD 的差异。计算了中国人群中 1 级 VF 的患病率。还评估了 1 级组中三种骨折类型的 BMD 差异。
共纳入 3652 名参与者（男性 1799 名，54.85±9.02 岁，范围 40-92 岁；女性 1853 名，56.00±9.08 岁，范围 40-93 岁）。2 级和 3 级的患病率随年龄增长而增加。1 级 VF 的患病率在≤50 岁至 60-69 岁组逐渐增加，但在≥70 岁男性组（6.6%）和女性组（25.5%）中下降。年龄<50 岁的男性组和女性组中，1 级组与无骨折组的椎体形态指数（VSI）和 BMD 无显著统计学差异，除了男性的楔形指数。50-59 岁男性组中，非骨折组与 1 级组的双凹指数无差异，而女性组有显著统计学差异。此外，BMD 的结果与这些发现一致。对于 40-59 岁年龄组，压缩变形组与其他组之间存在显著差异。
与非骨折组相比，1 级组的 VSI 更高，BMD 更低，提示 1 级组与女性 50 岁以上、男性 60 岁以上人群的骨质疏松症有关。不同骨折类型在中年人群中的 BMD 存在显著差异。1 级 VF 的患病率在两性中均随年龄增长而增加，且老年男性与女性的趋势相反。我们建议 VSI 可帮助医生诊断 1 级 VF。
