Department of Physiotherapy, Centre for Podiatry and Diabetic Foot Care and Research (CPDFCR), Manipal College of Health Professions (MCHP), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.
Department of Nephrology, Kasturba Medical College (KMC)-Manipal, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.
Int Urol Nephrol. 2024 Aug;56(8):2671-2682. doi: 10.1007/s11255-024-03987-w. Epub 2024 Mar 14.
Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy.
A total of 283 individuals were screened and 60 eligible participants aged 45-70 years with diabetic nephropathy were randomly allocated (n = 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week.
The repeated measures ANOVA with Greenhouse-Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F = 619, p < 0.001, serum creatinine F = 174.8, p < 0.001, estimated glomerular filtration rate F = 105.2, p < 0.001, serum urea F = 261.4, p < 0.001 and urine protein F = 4.58, p < 0.328.
The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.
糖尿病肾病是一个日益严重的公共卫生挑战，对健康有影响。由于多种肾脏表现的发展，肾功能下降会影响糖尿病肾病患者的功能能力和整体健康和幸福感。本研究的目的是确定基于运动的康复计划对 2 型糖尿病肾病患者的功能能力和肾功能的影响。
共筛选了 283 名患者，纳入了 60 名年龄在 45-70 岁之间的、患有糖尿病肾病的合格参与者，将他们随机分配（每组 30 人）到干预组（IG）和对照组（CG）。研究的结局指标包括功能能力（6 分钟步行试验）和基线、12 周和 24 周的肾功能。分配到 IG 的参与者接受了 12 周的基于运动的康复（包括监督+家庭运动）以及标准护理，并随访至 24 周。
经 Greenhouse-Geisser 校正的重复测量方差分析显示，6 分钟步行距离 F=619，p<0.001、血清肌酐 F=174.8，p<0.001、估计肾小球滤过率 F=105.2，p<0.001、血清尿素 F=261.4，p<0.001 和尿蛋白 F=4.58，p<0.328 的时间点*组交互效应具有显著意义。
研究发现，基于运动的康复改善了 2 型糖尿病肾病患者的功能能力和肾功能。
