Michou Vasiliki, Tsamos Georgios, Vasdeki Dimitra, Kouidi Evangelia, Deligiannis Asterios
Sports Medicine Laboratory, School of Physical Education & Sport Science, Aristotle University, 57001, Thessaloniki, Greece.
Division of Endocrinology and Metabolism and Diabetes Centre, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 546 36, Thessaloniki, Greece.
J Nephrol. 2025 Mar;38(2):457-471. doi: 10.1007/s40620-025-02216-6. Epub 2025 Feb 6.
Patients with Diabetic Kidney Disease (DKD) suffer from various complications of diabetes mellitus, including autonomic neuropathy. Cardiac autonomic nervous system dysfunction is a common disorder in patients with diabetes mellitus and Chronic Kidney Disease (CKD), and is associated with an increased risk of arrhythmias and cardiovascular morbidity and mortality. Although the effects of exercise training have been thoroughly studied in different patient populations with CKD or diabetes mellitus, few studies have investigated the effects of exercise on cardiac autonomic nervous system activity in patients with DKD. This narrative review aims to summarize the evidence regarding the effects of exercise training on cardiac autonomic nervous system modulation in DKD patients.
糖尿病肾病（DKD）患者会出现糖尿病的各种并发症，包括自主神经病变。心脏自主神经系统功能障碍是糖尿病和慢性肾脏病（CKD）患者的常见病症，与心律失常风险增加以及心血管疾病的发病率和死亡率相关。尽管运动训练对不同的CKD或糖尿病患者群体的影响已得到充分研究，但很少有研究调查运动对DKD患者心脏自主神经系统活动的影响。本叙述性综述旨在总结有关运动训练对DKD患者心脏自主神经系统调节作用的证据。
