Trujillo Ander Bengoechea, Sagar Drishti, Amaravadhi Amoolya Rao, Muraleedharan Devika, Malik Muhammad Zauraiz, Effa-Ababio Kofi, Nsengiyumva Mugisha, Tesfaye Tadele, Walędziak Maciej, Różańska-Walędziak Anna
Hospital Universitario Puerta del Mar, 11009, Cádiz, Spain.
Aakash Healthcare Superspeciality Hospital, Sector-3, Dwarka, Delhi, 110075, India.
Obes Surg. 2024 May;34(5):1874-1884. doi: 10.1007/s11695-024-07163-y. Epub 2024 Mar 14.
Gastroesophageal reflux disease (GERD) is a common concern following laparoscopic sleeve gastrectomy (LSG). This paper aimed to assess the incidence of reflux disease following these bariatric procedures. A literature search was conducted to identify observational studies and clinical trials reporting patients developed GERD disease after LSG. Twenty-two studies included in the analysis, involve 20,495 participants, indicated that the estimated proportion of patients who developed post-surgery GERD was 0.35 (95% CI 0.30-0.41). Subgroup analysis revealed a proportion of 0.33 (95% CI 0.27-0.38) in observational studies and 0.58 (95% CI 0.39-0.75) in clinical trials. High heterogeneity was noted across studies (I = 98%). Sensitivity analyses and publication bias assessments were performed to enhance the robustness of the results. Our findings highlight a moderate to high risk of developing GERD following LSG surgery.
胃食管反流病（GERD）是腹腔镜袖状胃切除术（LSG）后常见的问题。本文旨在评估这些减肥手术后反流病的发生率。通过文献检索以确定报告LSG术后患者发生GERD疾病的观察性研究和临床试验。纳入分析的22项研究涉及20495名参与者，结果表明，术后发生GERD的患者估计比例为0.35（95%CI 0.30 - 0.41）。亚组分析显示，观察性研究中的比例为0.33（95%CI 0.27 - 0.38），临床试验中的比例为0.58（95%CI 0.39 - 0.75）。各研究间存在高度异质性（I² = 98%）。进行了敏感性分析和发表偏倚评估以增强结果的稳健性。我们的研究结果突出了LSG手术后发生GERD的中到高风险。
