Department of Zoology, School of Basic and Applied Sciences, Raffles University, Neemrana, Rajasthan, 301705, India.
Senior Analyst, Pashmina Certification Centre, Wildlife Institute of India (WII), Dehradun, Uttarakhand, 248001, India.
Cell Biochem Biophys. 2024 Jun;82(2):873-883. doi: 10.1007/s12013-024-01238-4. Epub 2024 Mar 14.
Nucleoside analogs are a common form of chemotherapy that disrupts DNA replication and repair, leading to cell cycle arrest and apoptosis. Reactive oxygen species (ROS) production is a significant mechanism through which these drugs exert their anticancer effects. This study investigated a new nucleoside analog called FNC or Azvudine, and its impact on ROS production and cell viability in Dalton's lymphoma (DL) cells. The study found that FNC treatment resulted in a time- and dose-dependent increase in ROS levels in DL cells. After 15 and 30 min of treatment with 2 and 1 mg/ml of FNC, mitochondrial ROS production was observed in DL cells. Furthermore, prolonged exposure to FNC caused structural alterations and DNA damage in DL cells. The results suggest that FNC's ability to impair DL cell viability may be due to its induction of ROS production and indicate a need for further investigation.
核苷类似物是一种常见的化疗药物，可破坏 DNA 复制和修复，导致细胞周期停滞和细胞凋亡。活性氧（ROS）的产生是这些药物发挥抗癌作用的重要机制。本研究探讨了一种名为 FNC 或阿兹夫定的新型核苷类似物，及其对 Dalton's 淋巴瘤（DL）细胞中 ROS 产生和细胞活力的影响。研究发现，FNC 处理导致 DL 细胞中 ROS 水平呈时间和剂量依赖性增加。用 2 和 1mg/ml 的 FNC 处理 15 和 30 分钟后，观察到 DL 细胞中线粒体 ROS 的产生。此外，长时间暴露于 FNC 会导致 DL 细胞的结构改变和 DNA 损伤。结果表明，FNC 降低 DL 细胞活力的能力可能与其诱导 ROS 产生有关，这表明需要进一步研究。
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