Inner Mongolia Medical University, No. 5, Xinhua Road, Hohhot, Inner Mongolia 010059, China.
Shanghai Wei Er Lab, Shanghai 201707, China.
Colloids Surf B Biointerfaces. 2024 May;237:113838. doi: 10.1016/j.colsurfb.2024.113838. Epub 2024 Mar 11.
The emergence of nanotechnology has opened up a new way for tumor therapy. Among them, self-assembled nanotechnology has received extensive attention in medicine due to its simple preparation process, high drug-loading capacity, low toxicity, and low cost. This review mainly summarizes the preparation methods of self-assembled nano-delivery systems, as well as the self-assembled mechanism of carrier-free nanomedicine, polymer-carried nanomedicine, polypeptide, and metal drugs, and their applications in tumor therapy. In addition, we discuss the advantages and disadvantages, future challenges, and opportunities of these self-assembled nanomedicines, which provide important references for the development and application of self-assembled nanotechnology in the field of medical therapy.
纳米技术的出现为肿瘤治疗开辟了新途径。其中，自组装纳米技术因其制备工艺简单、载药量大、毒性低、成本低等优点，在医学领域受到广泛关注。本文主要综述了自组装纳米递药系统的制备方法，以及无载体纳米药物、聚合物载体纳米药物、多肽和金属药物的自组装机制及其在肿瘤治疗中的应用。此外，还讨论了这些自组装纳米药物的优缺点、未来挑战和机遇，为自组装纳米技术在医学治疗领域的发展和应用提供了重要参考。
