School of Pharmacy, Shanghai Jiao Tong University, 800, Dongchuan Road, Shanghai 200240, China.
J Mater Chem B. 2019 Dec 11;7(48):7639-7655. doi: 10.1039/c9tb01842e.
The applications of nanoparticulate drug delivery have received abundant interest in the field of cancer diagnosis and treatment. By virtue of their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine has spanned multitudes of drug delivery systems that possess high tumor targeting ability, sensitivity towards tumor microenvironments and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, i.e., liposomes, micelles, nanotubes, dendrimers and peptides, offer a wide range of advantages, such as high selectivity, multi-functionality, specificity, biocompatibility and precise control of drug release. Nanomedicines based on self-assembled peptide carrier systems have been developed in recent years for cancer targeting. Self-assembled peptides have tremendous properties of forming targeted drug delivery vehicles such as nanohydrogels with unique features and functionality. In this review article, we discuss some developments in cancer nanomedicine. We present a diverse range of nanotargeted drug-delivery systems.
纳米颗粒药物输送在癌症诊断和治疗领域受到了广泛关注。由于其独特的特性和设计，纳米药物在消除可怕的肿瘤方面取得了显著进展。癌症纳米医学的研究已经涵盖了多种具有高肿瘤靶向能力、对肿瘤微环境敏感和提高疗效的药物输送系统。已经开发和批准了各种纳米载体用于抗肿瘤药物靶向。这些纳米载体，如脂质体、胶束、纳米管、树枝状聚合物和肽，提供了广泛的优势，如高选择性、多功能性、特异性、生物相容性和精确控制药物释放。近年来，基于自组装肽载体系统的纳米药物已被开发用于癌症靶向。自组装肽具有形成靶向药物输送载体的巨大特性，例如具有独特特征和功能的纳米水凝胶。在这篇综述文章中，我们讨论了癌症纳米医学的一些发展。我们提出了一系列不同的纳米靶向药物输送系统。
