取代的2-吡喃酮、2-吡啶酮以及弹性蛋白的其他同系物作为治疗慢性阻塞性肺疾病的潜在药物。
Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases.
作者信息
Groutas W C, Stanga M A, Brubaker M J, Huang T L, Moi M K, Carroll R T
出版信息
J Med Chem. 1985 Aug;28(8):1106-9. doi: 10.1021/jm00146a023.
PMID:3848491
Abstract
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE). The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be the most effective inhibitors of the enzyme. These compounds are highly specific in their inhibitory activity.
摘要
已经合成了弹性蛋白（I）的几种同系物，并显示它们能够抑制人白细胞弹性蛋白酶（HLE）。发现C-3烷基取代的2-吡喃酮11和12是该酶最有效的抑制剂。这些化合物的抑制活性具有高度特异性。
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