取代α-吡喃酮对人白细胞弹性蛋白酶的特异性抑制作用
Specific inhibition of human leukocyte elastase by substituted alpha-pyrones.
作者信息
Groutas W C, Abrams W R, Carroll R T, Moi M K, Miller K E, Margolis M T
出版信息
Experientia. 1984 Apr 15;40(4):361-2. doi: 10.1007/BF01952552.
Several a-pyrones have been synthesized and investigated for their in vitro inhibitory activity using a-chymotrypsin (a-CT), porcine pancreatic elastase (PPE) and human leukocyte elastase (HLE). 4-Hydroxy-6-undecyl-2H-pyran-2-one 4, 4-Hydroxy-6-[(1-butyl)heptyl]-2H-pyran-2-one 5 and 4-Methoxy-6-[(1-butyl) heptyl]-2H-pyran-2-one 6 were found to be specific inhibitors of HLE. These compounds constitute a promising new class of HLE inhibitors.
已经合成了几种α-吡喃酮，并使用α-胰凝乳蛋白酶（α-CT）、猪胰弹性蛋白酶（PPE）和人白细胞弹性蛋白酶（HLE）研究了它们的体外抑制活性。发现4-羟基-6-十一烷基-2H-吡喃-2-酮4、4-羟基-6-[(1-丁基)庚基]-2H-吡喃-2-酮5和4-甲氧基-6-[(1-丁基)庚基]-2H-吡喃-2-酮6是HLE的特异性抑制剂。这些化合物构成了一类有前景的新型HLE抑制剂。
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